Contact:
YCR P53 Research Unit
Department of Biology
University of York
YORK YO10 5DD, UK.
Tel (within UK):
(01904) 328620
Fax: (01904) 328622
Tel (outside UK):
+44-1904-328620
Fax: +44-1904-328622
E-mail: ajm24@york.ac.uk
PUBLICATIONS | CHAPTERS IN BOOKS
Where possible links have been made to online abstracts or the source of publication.
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Year of Publication: 2010 : 2009 : 2008 : 2007 : 2006 : 2005 : 2004 : 2003 : 2002 : 2001 : 2000 : 1999 : 1998 : 1997 : 1995
2010
Baxter E.W. and Milner J.
p53 regulates LIF expression in human medulloblastoma cells.
J Neurooncol. 97: 373-82 (2010) Abstract
2009
Ahmed S.U. and Milner J.
Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network.
PLoS ONE. 4: 10 e7305 (2009) Abstract
Allison S.J., Jiang M. and Milner J.
Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells.
Aging. 1: 316-327 (2009) Abstract
Milner J.
Cellular Regulation of SIRT1.
Curr. Pharm. Des. 15: 39-22 (2009) Abstract
2008
Ford J., Ahmed S., Allison S., Jiang M. and Milner J.
JNK2-dependent regulation of SIRT1 protein stability.
Cell Cycle 7: 3091-3097 (2008) Abstract
Warnock L.J., Adamson, R. Lynch C.J. and Milner J.
Crosstalk between site-specific modifications on p53 and histone H3.
Oncogene. 27: 1639-1644 (2008) Abstract
Allison S.J. and Milner J.
SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways.
Cell Cycle. 6: 2668-2678 (2007) Abstract
2006
Okorokov A., Sherman M.B., Plisson C., Grinkevich V., Sigmundsson K., Selivanova G., Milner J. and Orlova E.V.
The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.
EMBO J. 25: 5191-5200 (2006) Abstract
Lynch C. and Milner J.
Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency.
Oncogene. 25: 3463-3470 (2006) Abstract
Ford J.R., Jiang M. and Milner J.
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.
Cancer Res. 65: 10457-10463. (2005) Abstract
Bochkareva E., Kaustov L., Ayed A., Yi G-S., Lu Y., Pineda-Lucena A., Liao J.C.C., Okorokov A.L., Milner J., Arrowsmith C.H. and Bochkarev A.
Single-stranded mimicry in the p53 transactivation domain interaction with replication protein A.
Proc. Natl. Acad. Sci. 102: 15412-15417. (2005) Abstract
Jiang M., Arzumanov A.A., Gait M. and Milner J.
A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification.
Nucleic Acids Res. 33: e151-(2005) Abstract
Warnock L.J., Raines S.A., Mee T.R. and Milner J.
Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins.
E. J. Biochem. 272: 1669-1675. (2005) Abstract
Jiang M.J. and Milner J.
Gel-based application of siRNA to human epithelial cancer cells induces RNAi-dependent apoptosis.
Oligonucleotides. 14: 239-48. (2004) Abstract
Allison S.J. and Milner J.
Remodelling chromatin on a global scale: a novel protective function of p53.
Carcinogenesis. 25: 1551-1557. (2004) Abstract
Warnock L.J. and Raines S.A.
Restoration of wild-type conformation to full-length and truncated p53 proteins.
Cancer Biol. Ther. 3: 634-637. (2004) Abstract
Milner J.
Death without stress - the stiletto approach against disease.
The Biochemist. 26: 16-18. (2004) Abstract
Seker H., Rubbi C., Linke S.P., Bowman E.D., Garfield S., Hansen L., Borden K.L., Milner J. and Harris C.C.
UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.
Oncogene. 22: 1620-1628. (2003) Abstract
Jiang M. and Milner J.
Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells.
Genes Dev. 17: 832-837. (2003) Abstract
Milner J.
RNA interference for treating cancers caused by viral infection.
Exp. Opin. Biol. Ther. 3: 459-467. (2003) Abstract
Rubbi C.P. and Milner J.
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.
EMBO J. 22: 6068-6077. (2003) Abstract
Rubbi C.P. and Milner J.
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage.
EMBO J. 22: 975-986. (2003) Abstract
Crighton D., Woiwode A., Zhang C., Mandavia N., Morton J.P., Warnock L.J., Milner J., White R.J., and Johnson D.L.
p53 represses RNA polymerase III transcription by targeting the TBP and inhibiting promoter occupancy by TFIIIB.
EMBO J. 22: 2810-2820. (2003) Abstract
Rubbi C.P. and Milner J.
p53 - guardian of a genome's guardian?
Cell Cycle. 2: 20-21. (2003) Pubmed
Allison S.J. and Milner J.
Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy.
Cancer Res. 63: 6674-6679. (2003) Abstract
Jiang M. and Milner J.
Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference.
Oncogene. 21: 6041-6048. (2002) Abstract
Stein T., Crighton D., Warnock L.J., Milner J. and White R.J.
Several regions of p53 are involved in repression of RNA polymerase III transcription.
Oncogene. 21: 5540-5547. (2002) Abstract
Okorokov A.L., Warnock L. and Milner J.
Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.
Carcinogenesis. 23: 549-557. (2002) Abstract
Okorokov A.L., Rubbi C.P., Metcalfe S. and Milner J.
The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.
Oncogene. 21: 356-367. (2002) Abstract
Rubbi C.P. and Milner J.
Analysis of nucleotide excision repair by detection of single-stranded DNA transients.
Carcinogenesis. 22: 1789-1796. (2001) Abstract
Jiang M., Axe T., Holgate R., Rubbi C.P., Okorokov A.L., Mee T. and Milner J.
p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.
Oncogene. 20: 5449-5458. (2001) Abstract
Metcalfe S., Wheeler T.K., Picken S., Negus S. and Milner J.
P53 autoantibodies in 1006 patients followed up for breast cancer.
Breast Cancer. 2: 438-442. (2000) Abstract
Rubbi C.P. and Milner J.
Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus.
Oncogene. 19: 85-96. (2000) Abstract
Okorokov A.L. and Milner J.
An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes.
Mol. Cell. Biol. 19: 7501-7510. (1999) Abstract
Veldhoen N., Watterson J., Brash M. and Milner J.
Identification of tumour-associated and germ line p53 mutations in canine mammary cancer.
Br. J. Cancer. 81: 409-415. (1999) Abstract
Veldhoen N. and Milner J.
Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein.
Oncogene. 16: 1077-1084. (1998) Abstract
Okorokov A.L., Ponchel F. and Milner J.
Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53.
EMBO J. 16: 6008-6017. (1997) Abstract
Pariat M., Carillo S., Molinari M., Slavat C., Debussche L., Bracco L., Milner J. and Piechaczyk M.
Proteolyis by calpains: a possible contribution to degradation of p53.
Mol. Cell. Biol. 17: 2806-2815. (1997) Abstract
Milner J.
DNA damage, p53 and anticancer therapies.
Nat. Med. 1: 879-880. (1995) Pubmed
Milner J.
Flexibility: the key to p53 function?
Trends Biochem. Sci. 20: 49-51. (1995) Pubmed
Rubbi C.P. and Milner J.
P53: Gatekeeper, caretaker or both?
in 25 years of p53 . Edited by P Hainaut and K G Wiman. publ. Springer, 2005.
Milner J. and Jiang M.
Selective silencing of viral gene E6 and E7 expression in HPV-Positive human cervical carcinoma cells using small interfering RNAs.
in Methods in Molecular Biology. Edited by P M Lieberman, publ. Humana Press, 2004.
Funded by Yorkshire Cancer Research, an independent cancer charity.