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Paul Kaye is Professor of Immunology at the University of York. He trained in zoology (BSc) and immunology (PhD) and has worked for over 30 years on the immunology and immunopathology of the neglected tropical disease leishmaniasis. He is internationally recognized for his research on macrophages and dendritic cells, contributing to a fundamental understanding of their biology in health and disease, and for his work on lymphoid tissue remodelling and granulomatous inflammation during chronic infection. Paul is a Wellcome Trust Senior Investigator and an elected Fellow of the UK Academy of Medical Sciences. He was awarded FRCPath by publication in 2004 and has published ~150 research articles and reviews, with numerous in leading international journals (e.g. Nature Medicine, Immunity, J. Clin. Invest., PNAS). Paul’s research tackles leishmaniasis from a holistic viewpoint, rooted in the immunology of the host-parasite interaction, but employing tools and approaches taken from many disciplines, including mathematics, ecology, vector biology and neuroscience. He has extensive links with leishmaniasis-endemic countries and is currently leading a Phase II therapeutic vaccine trial in Sudan and developing a digital pathology platform to facilitate a greater understanding of disease pathogenesis through data sharing and collaboration across geographic borders.
Paul's laboratory continues to focus on the immunopathology of leishmaniasis, with emphasis both on exploring opportunities for developing novel host-directed therapies and also for gaining new insight into myeloid cell function. Ongoing projects span fundamental research into macrophage and dendritic cell development, heterogeneity and function, studies on the immunological determinants of transmission to sand flies, research on human immunopathology, and clinical trials of a new vaccine for leishmaniasis. His research group has active collaborations in Brazil, India, Sri Lanka and across East Africa.
2-photon intravital microscopy, immuno-histochemistry, functional genomics; computational immunology; gene targeted models of chronic infection / inflammation; sand fly transmission; digital pathology; early phase clinical trials.
|Mohamed Osman||PDRA||Leishmaniasis vaccine development|
|Joe Doehl||PDRA||Leishmaniasis transmission|
|Audrey Romano||PDRA||Leishmaniasis transmission|
|Rebecca Wiggins||Clinical Trial Manager||Leishmaniasis vaccines|
|Sarah Forrester||PDRA||CRACK-IT Challenge / Leishmaniasis transmission|
|Jonathan Hamp||PhD student (joint with Jon Timmis)||Leishmaniasis PKPD modeling|
|Helen Ashwin||Research technician||CRACK-IT Challenge|
|Najmeeyah Brown||Research technician||Leishmaniasis transmission|
|Frances Drachenburg||PhD student (CIDCATS)||Systems Immunology modelling|
|Gulab Rani||PhD student (joint with Ian Hitchcock)||Immuno-hematology|
|Liz Greensted||Project Manager||LeishPathNet|
Grants as PI
For application requirements, process, and guidelines please see the postgraduate study pages of the Department of Biology website (http://www.york.ac.uk/biology/postgraduate/). New available studentships are announced on these web pages, the Departmental site and on FindAPhD.
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