The group studies microRNA-mediated silencing, a core molecular process required for mammalian cell development, homeostasis, and response to pathogenic and pathologic challenges. Currently, there are three main themes of research in the group:
1. MicroRNA-mediated silencing and the interplay between immunity and angiogenesis
We investigate the role of microRNA-mediated silencing in the interaction between vasculature and immune cells in chronic disease and the effects of anti-angiogenic agents and immune checkpoint regulators on both systems.
2. Signal trandusction and microRNA-mediated silencing
Our work aims to discover mechanisms that govern microRNA-mediated silencing. The group employs a wide range of approaches, from single molecule to whole organism, and from hypothesis-driven functional genomics and transcriptomics to computational biology techniques (see York Computational Immunology Lab), to dissect how the cross-talk between cell signalling cascades and the microRNA machinery determines cellular function.
3. MicroRNAs as diagnostic and prognostic disease biomarkers
The group is developing pipelines that translate functional genomics into routine blood tests used for patient stratification and rational use of antibiotics and biologics.
The group is funded by The Medical Research Council (New Investigator Research Grant), The Wellcome Trust (CIDCATS PhD Training Program and Centre for Chronic Diseases and Disorders), and The BBSRC (DTP in Mechanistic Biology). The Group has also received grants from The Royal Society, and Yorkshire Cancer Research.
|James Hewitson||PDRA, MRC||The role of miR-132 in immune responses.|
|Daniel Yee||BBSRC DTP PhD Student||MicroRNAs in lymphatic endothelial cell responses to inflammation.|
|Shoumit Dey||CIDCATS – Wellcome Trust PhD Student||MicroRNAs in innate immunity.|
|Alex Heyam||CIDCATS – Wellcome Trust PhD Student (Primary Supervisor: Michael Plevin)||
Biophysical studies of the microRNA biogenesis machinery.
My teaching in the Hull York Medical School and Department of Biology is inherently connected to my research interests including gene expression regulation in the immune system, host pathogen interactions, and the fundamental principles of molecular cell biology. I am the HYMS Phase 1 Lead for the Scholarship and Special Interest Programme and member of several committees overseeing curriculum development and delivery in both Biology and HYMS.
Stage 2 Immunology, Stage 3 Principles of Molecular Virology, Stage 3 Mechanisms to Therapies, HYMS Block 1, 4, 9.
Basic skills in biological sciences (Stage 1). HYMS SSIP on Host/Pathogen interactions (Phase 1)
MicroRNA biology: from mechanism to function
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