Infection And Immunity-h272

 
CII - Research impacts beyond academia 

Researchers at York address fundamental aspects of how pathogens interact with their hosts and how the host responds to them.  Much of this work has direct translational potential and work undertaken within the Centre for Immunology and Infection, run jointly with HYMS, illustrates our integrative approach to modern biomedical research.  Our scientists and clinicians conduct research spanning molecular genetics, immunology, cell biology, and advanced imaging, computational modelling and human clinical trials.

Impact

Research undertaken in Infection and Immunity impacts on the global challenge “impacting on health and disease”, through developing novel vaccines, identifying new drug targets and establishing new immunotherapeutic models

Smith-LeishmaniaParasite

From bench to bedside (and back)

New therapeutic vaccine for leishmaniasis

Coles - Lymph Node Imaging

Understanding chronic disease

Thymus migration during development

Smith - Trypanosome Lacking Protein

How cells and pathogens really work

New drugs hope to fight neglected tropical disease

Examples of Infection and Immunity projects

STROMA is an FP7 funded European Marie Curie Training network led from York consisting of academic and industrial researchers looking into the function of these important class of cells in health and disease.

CIDCATS (Combating Infectious Disease: Computational Approaches in Translational Science) is an interdisciplinary PhD Programme in Infectious Disease funded by the Wellcome Trust.  It focuses on Drug Target Development, Predictive Modelling of Pathogenesis and Treatment Response and Development of Novel Tools for Complex Data Analysis.

LEISH1 a first-in-man clinical trial sponsored by the University of York and the York Hospital NHS Foundation Trust.  Led from York, this clinical trial is the final stage of a Wellcome Trust Translation Award involving researchers from the UK, Germany and India, and represents the first live viral vectored vaccine for this disease to be tested in man.

 

Examples of high profile publications

Horizontally Acquired Glycosyltransferase Operons Drive Salmonellae Lipopolysaccharide Diversity. Davies et al. PLoS Genetics 2013

Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation. Morrison et.al. Mucosal Immunol. 2013

N-Myristoyltransferase inhibitors: new leads for the treatment of human African Trypanosomiasis. Frearson et al. 2010, Nature

Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice. Dalton et al. 2010, Journal of Clinical Investigation

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator. Lagos et al. 2010, Nature Cell Biology

Phase I randomised clinical trial of an HIV-1CN54, clade C, trimeric envelope vaccine candidate delivered vaginally. Lewis et al. 2011, PLoS ONE

TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Fox et al. 2011, BLOOD

Abrogation of CD40-CD154 signals impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development. Cuss et al. 2012, Journal of Immunology