The Centre for Immunology and Infection is structured into three overlapping research areas: clinical and translational research (from bench to bedside (and back)), immunology (understanding chronic disease), and pathogen biology (how cells and pathogens really work).
From bench to bedside (and back) research is centered largely on clinical trials. We conduct phase 1 trials of mucosal vaccines and microbicides against HIV-1, with a focus on finding safe, effect and easily accessible interventions for women in developing countries. Other gential tract infections investigated in human volunteers include Chlamydia and HPV.
Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial Sheena McCormack*, David T Dunn*, Monica Desai, David I Dolling, Mitzy Gafos, Richard Gilson, Ann K Sullivan, Amanda Clarke, Iain Reeves, Gabriel Schembri, Nicola Mackie, Christine Bowman, Charles J Lacey, Vanessa Apea, Michael Brady, Julie Fox, Stephen Taylor, Simone Antonucci, Saye H Khoo, James Rooney, Anthony Nardone, Martin Fisher, Alan McOwan, Andrew N Phillips, Anne M Johnson, Brian Gazzard, Owen N Gill. Lancet 2015 Sep 9.
Our research in immunology, which underpins our disease-specific interests, is focused on the biology of three critical components of immunity: phagocytes, lymphocytes and stromall cells.
The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection. / Dalton, Jane Elise; Glover, Amy C.; Hoodless, Laura; Lim, Eng Kiat; Beattie, Lynette; Kirby, Alun; Kaye, Paul M.
In: PLOS PATHOGENS, Vol. 11, No. 2, e1004681, 24.02.2015.
Morrison, PJ, SJ Ballantyne, SJ Macdonald, JWJ Moore, D Jenkins, JF Wright, LA Fouser, and MC Kullberg. (2015) Differential requirements for IL-17A and IL-22 in cecal versus colonic inflammation induced by Helicobacter hepaticus. Am J Path 185: 3290-3303.
Pathogen research includes studies on Gram-negative Enterobacteriaceae, specifically E. coli, Salmonella and Klebsiella spp, on the kinetoplastid parasites, and on the liver fluke Schistosoma. We are using genetic, cellular and molecular biology approaches to understand the mechanisms of disease and identify drug targets.
Kintz, E. Davies, MR, Hammarlӧf, D.L., Canals R. Hinton, J.C.D., and van der Woude M. (2015) A BTP1 prophage gene present in invasive non-typhoidal Salmonella determines composition and length of the O-antigen of the LPS. Mol Microbiol. doi: 10.1111/mmi.12933
Fernandez-Cortes F, Serafim TD, Wilkes JM, Jones NG, Ritchie R, McCulloch R, Mottram JC. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Sci Rep. 2017 Jul 21;7(1):6156. doi: 10.1038/s41598-017-06501-8
James M. Fox, Richard Kasprowicz, Oliver Hartley and Nathalie Signoret CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells
J Leukoc Biol July 2015 98:59-71; doi:10.1189/jlb.2A0414-193RR