Collaborative research to better understand immunological synapses

Posted on 22 May 2018

Collaborative research led by CII HYMS Senior Lecturer in Immunology Nathalie Signoret has shed new light on immunological synapses

This publication demonstrates a new way to analyse image data to give greater value than the classic methods. In this instance we have used it to identify a new and rare form of contact-based cell communication between white blood cells that would otherwise be lost within the data itself. This method has the potential to be applied to many different fields of biomedical life science research to really help us understand the finer details of fundamental cell mechanisms and to tackle diseases resulting from their breakdown.

The research was published in a manuscript entitled: "A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses" and involved cross-departmental collaboration between the authors: Richard Kasprowicz, Emma Rand, Peter J. O’Toole & Nathalie Signoret. Citation details are: Scientific Reports, volume 8, Article number: 8003 (2018), doi:10.1038/s41598-018-26172-3

Link to paper published 22-May-2018 in Scientific Reports