Dr Johan Turkenburg

Office: 01904 328251
X-ray lab:  01904 328274
Email: johan.turkenburg@york.ac.uk

X-ray Facilities Manager (YSBL)

Research Interests

My main interest is the application of crystallographic techniques to structural studies of biological macromolecules with an emphasis on (automation of) data collection both at home and at synchrotrons.

I am responsible for the in-house data collection facilities, and coordinate all aspects of the application for beam time at synchrotron facilities and of synchrotron data collection.I provide crystallographic expertise to many of the research groups within the YSBL, and install, test and make available crystallographic software.

I am involved in a variety of structural studies currently pursued in the laboratory. Most recently this has included glycoside hydrolases, proteinases, lipases and reductases.

I am also the Radiation Protection Supervisor for X-ray generators in the Departments of Chemistry and Biology.

More recently I have been involved with formulating the requirements for the housing and installation of the Cryo Electron Microscope.

External activities

Scientific organiser (with Prof. Leo Brady, Bristol) CCP4 Study Weekend 1999 "Data collection and processing"

Scientific organiser (with Dr. Katherine McCauley, Diamond Light Source) CCP4 Study Weekend 2005 "Data collection and processing"

Member of the Diamond User Committee for the MX Village (2009-2011)

Member of the User Working Group for the Long wavelength beamline I23 at Diamond Light Source

Member of the User Working Group for the in-situ beamline VMXi at Diamond Light Source

Co-organiser of the CCP4/BCA Protein Crystallography Summer School 2017 at St Andrews (with Dr. Tracey Gloster)

Selected Publications

For a full list of publications see http://orcid.org/0000-0001-6992-6838

  • Interactions of the periplasmic binding protein CeuE with Fe(III) n-LICAM(4-) siderophore analogues of varied linker length.  
    Wilde, E. J., Hughes, A., Blagova, E. V., Moroz, O. V., Thomas, R. P., Turkenburg, J. P., Raines, D. J., Duhme-Klair, A. K. & Wilson, K. S. (2017), Sci Rep-Uk 7.
  • Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. 
    Palivec, V., Viola, C. M., Kozak, M., Ganderton, T. R., Krizkova, K., Turkenburg, J. P., Haluskova, P., Zakova, L., Jiracek, J., Jungwirth, P. & Brzozowski, A. M. (2017), J Biol Chem 292, 8342-8355.
  • Structural and functional insights into asymmetric enzymatic dehydration of alkenols.  
    Nestl, B. M., Geinitz, C., Popa, S., Rizek, S., Haselbeck, R. J., Stephen, R., Noble, M. A., Fischer, M. P., Ralph, E. C., Hau, H. T., Man, H., Omar, M., Turkenburg, J. P., van Dien, S., Culler, S. J., Grogan, G. & Hauer, B. (2017), Nature Chemical Biology 13, 275-+.
  • Rational steering of insulin binding specificity by intra-chain chemical crosslinking.  
    Vikova, J., Collinsova, M., Kletvikova, E., Budesinsky, M., Kaplan, V., Zakova, L., Veverka, V., Hexnerova, R., Avino, R. J. T., Strakova, J., Selicharova, I., Vanek, V., Wright, D. W., Watson, C. J., Turkenburg, J. P., Brzozowski, A. M. & Jiracek, J. (2016), Sci Rep-Uk 6.
  • Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis product.  
    Raines, D. J., Moroz, O., Blagova, E. V., Turkenburg, J. P., Wilson, K. S. & Duhme-Klair, A. K. (2016), P Natl Acad Sci USA 113, 5850-5855.
  • Three-dimensional structures of two heavily N-glycosylated Aspergillus sp family GH3 beta-D-glucosidases.  
    Agirre, J., Ariza, A., Offen, W. A., Turkenburg, J. P., Roberts, S. M., McNicholas, S., Harris, P. V., McBrayer, B., Dohnalek, J., Cowtan, K. D., Davies, G. J. & Wilson, K. S. (2016), Acta Crystallographica Section D-Structural Biology 72, 254-265.