My group's research is focused on the structural analysis of biologically-active molecules in order to understand better their mechanism of action at the molecular level. Our primary technique is mass spectrometry, which we use in conjunction with a wide variety of other analytical techniques, including chemical, enzymatic and separations strategies, principally for application in proteomic and metabolomic studies. The group's research has an emphasis on pursuing long-term, integrated studies of biological systems, which means that multidisciplinary collaborations are of prime importance; we are very fortunate in having a range of ongoing projects with a set of long-term and expert collaborators.
Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR) - one of the Centre of Excellence in Mass Spectrometry research instruments in use by the JTO group
Using these approaches, we are currently working on characterising: