Professor Gideon J. Grogan
+44 (0)1904 328256
Email: gideon.grogan@york.ac.uk
Structural and Applied Enzymology
Gideon Grogan works on the identification, characterisation and application of new enzymes that have potential applications in biotechnology, including those for the production of chiral pharmaceutical precursors and the bioprocessing of renewable materials. Recent work has focused on:
- Oxygenases, including P450s, flavin monooxygenases and Unspecific Peroxygenases
- Reductases, including those that act on prochiral ketones (KREDs), imines (IREDs) and enzymes that catalyse reductive amination reactions (RedAms, nat-AmDHs)
- Amide Bond Synthetases.
- Enzymes from plant biosynthetic pathways
In each case, a multidisciplinary approach is adopted, involving synthetic chemistry, microbiology, molecular biology, and X-ray crystallography, with a view to engineering enzymes using in vitro evolution techniques for altered or improved characteristics.
Recent Selected Publications
- Asymmetric Synthesis of stereogenic-at-sulfur compounds via biocatalytic oxidation with Unspecific Peroxygenases, Li et al., Nature Commun., 2026, 17, 646.
- Nicotine biosynthesis is completed by cryptic activating glucosylation, Schwabe et al., Nature Commun., 2026, 17, 4221.
- Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenase, Li et al. Angew. Chem. Int. Ed., 2025, 64, e202422241.
- A refined picture of the native amine dehydrogenase family revealed by extensive biodiversity screening, Elisée et al. Nature Commun., 2024, 15, 4933.
- Multifunctional Biocatalyst for Conjugate Reduction and Reductive Amination, Thorpe et al., Nature, 2022, 604, 86-91.
