Accessibility statement

Peter Rayner
Associate Lecturer



  • University of York
    MChem (2009)
  • University of York
    PhD in Organic Chemistry (2013)

Conferences Attended

Name of conference



In what capacity

Huddersfield Hyperpolarization



Oral Presentation ‘Synthetic strategies for the optimisation of SABRE’

JEOL Prize Seminar



Invited speaker ‘Tuning Hyperpolarisation
by Synthetic Design’

Dalton Division Northern Meeting




NMR Discussion Group





Title of Poster


Event title

Strategies for Optimising SABRE Catalysis


JEOL Post-doctoral Poster Seminar

Signal Amplification by Reversible Exchange


CHyM Steering Group

Tunable Catalysts for Hyperpolarisation


JEOL Post-doctoral Poster Seminar

Synthetic Approaches for Optimising SABRE


Dalton Division Northern Meeting

Novel Catalysts for SABRE Hyperpolarisation


NMR Discussion Group




Peter’s research interests broadly lie in the development of novel synthetic and catalytic chemistry for application in biological systems. His current work focuses on the development of the SABRE technique for use in diagnostic imaging. This interdisciplinary task encompasses the design and synthesis of isotopically labelled (2H, 13C, 15N) substrates and the invention of novel ligands for the SABRE catalyst which coupled together give strong polarisation levels and long magnetic lifetimes. A number of analytical techniques, such as NMR and infra-red spectroscopy, mass spectrometry and X-ray crystallography, are used to develop structure-activity relationships that are used to evolve the SABRE process.

Optimised substrates and catalysts are investigated pre-clinically for their MRI detection. This information will be used to develop disease state diagnosis as the SABRE technique progresses towards medical applications.

Peter’s Research in the Media

Molecules in the Body More Visible in New Detection System


Full publications list

A. Manoharan,  P. J. Rayner,  M. Fekete,  W. Iali,  P. Norcott,  V. H. Perry and S. B. Duckett, Catalyst‐Substrate Effects on Biocompatible SABRE Hyperpolarization, ChemPhysChem, 2018, DOI: 10.1002/cphc.201800915

W. Iali, P. J. Rayner, A. Alsherhri, A. J. Holmes, A. J. Ruddlesden and S. B. Duckett, Direct and Indirect hyperpolarisation of amines using parahydrogen, 2018, 9, 3677-3684 DOI: 10.1039/c8sc00526e 

P. J. Rayner, S. B. Duckett, Signal Amplification by Reversible Exchange (SABRE): From Discovery to Diagnosis, Angewandte Chemie-International Edition, 2018, DOI; 10.1002/anie.201710406

W. Iali, P. J. Rayner, S. B. Duckett, Using Parahydrogen to Hyperpolarize Amines, Amides, Carboxylic Acids, Alcohols, Phosphates and Carbonates, Science Advances, 2018, DOI: 10.1126/sciadv.aao6250 

P. Norcott, M.J. Burns, P. J. Rayner, R. E. Mewis, S. B. Duckett, Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE, Magnetic Resonance in Chemistry, 2018, DOI: 10.1002/mrc.4703

A. Manoharan, P. J. Rayner, W. Iali, M. J. Burns, V. H. Perry, S. B. Duckett, Achieving biocompatible SABRE: An in vitro cytotoxicity study, ChemMedChem, 2017, DOI: 10.1002/cmdc.201700725

S. S. Roy, G. Stevanato, P. J. Rayner, S. B. Duckett, Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE, J. Mag. Res. 2017, 285, 55 - 60, DOI:

P. Norcott,P. J. Rayner,G. G. R. Green, S. B. Duckett, Achieving High 1H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds, Chem. Eur. J., 2017,  23, 16990 - 16997, DOI:

M. Fekete, P. J. Rayner, G. G. R. Green, S. B. Duckett. Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability Magnetic Resonance in Chemistry, 2017, 55, 944-957, DOI: 10.1002/mrc.4607

S. S. Roy, P. Norcott, P. J. Rayner, G. G. R. Green, S. B. Duckett. A simple route to strong carbon-13 NMR signals detectable for several minutes, Chemistry, A European Journal, 2017, 23 (44), 10496-10500, doi: 10.1002/chem.201702767

P. J. Rayner, M. J. Burns, A. M. Olaru, P. Norcott, M. Fekete, G. G. R. Green, L. A. R. Highton, R. E. Mewis, S. B. Duckett.  Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange, Proc. Nat. Acad. Sci., 2017, 114, E3188-E3194, doi: 10.1073/pnas.1620457114

A. M. Olaru, A. Burt, P. J. Rayner, S. J. Hart, A. C. Whitwood, G. G. R. Green, S. B. Duckett, Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR Nuclei, Chem. Commun., 2016, 52, 14482.

P. J. Rayner, J. C. Smith, C. Denneval, P. O’Brien, P. A. Clarke, R. A. J. Horan, Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine, Chem. Commun., 2016, 52, 1354.

S. S. Roy, Norcott, P. P. J. Rayner, G. G. R. Green, S. B. Duckett. A Hyperpolarizable 1H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage. Angew. Chem. Int. Ed. 2016;55(50): 15642-15645 DOI: 10.1002/anie.201609186

S. S. Roy, P. J. Rayner, P. Norcott, G. G. R. Green, S. B. Duckett. Long-lived states to sustain SABRE hyperpolarised magnetisation, Phys. Chem. Chem. Phys., 2016, 18, 24905 DOI: 10.1039/C6CP02844F

P. Rovedo, S. Knecht, T. Baumlisberger, A. L. Creme, S. B. Duckett, R. E. Mewis, G. G. R. Green, M. J. Burns, P. J. Rayner, D. Leibfritz, J. G. Korvink, J. Hennig, G. Putz, D. von Elverfeldt, J-B. Hovener. Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarisation of a Biomolecule in Water, J. Phys. Chem. B, 2016, 120, 5670  10.1021/acs.jpcb.6b02830

M. J. Burns, P. J. Rayner, G. G. R. Green, L. A. R. Highton, R. E. Mewis, S. B. Duckett. Improving the Hyerpolarization of 31P Nuclei by Synthetic Design, J. Phys. Chem. B, 2015, 119 (15), pp 5020–5027. 10.1021/acs.jpcb.5b00686

A. J. Holmes, P. J. Rayner, M. J. Cowley, G. G. R. Green, A. C. Whitwood, S. B. Duckett. The reaction of an iridium PNP complex with parahydrogen facilitates polarisation transfer without chemical change. Dalton Transactions. 2015, 44(3), 1077-1083. 10.1039/c4dt03088e

R. E. Mewis, R. A. Green, M. C. R. Cockett, M. J. Cowley, S. B. Duckett, G. G. R. Green, R. O. John, P. J. Rayner, D. C. Williamson. Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE.  Journal of Physical Chemistry B, 2015, 119(4) 1416-1424. 10.1021/jp511492q

P. J. Rayner, G. Gelardi, P. O'Brien, R. A. J. Horan, P. C. Blakemore. On the synthesis of α-amino sulfoxides, Org. Biomol. Chem., 2014, 12, 3499. 10.1039/c4ob00567h

M. Fekete, O. Bayfield, S.B. Duckett, S. Hart, R. E. Mewis, N. Pridmore, P. J. Rayner, A. Whitwood. Iridium(III) Hydro N-Heterocyclic Carbene-Phosphine Complexes as Catalysts in Magnetization Transfer Reactions, Inorg. Chem., 2013, 52, 13453. 10.1021/ic401783c

P. J. Rayner, P. O'Brien, R. A. J. Horan. Preparation and Reactions of Enantiomerically Pure α-Functionalized Grignard Reagents, J. Am. Chem. Soc., 2013, 135, 8071. 10.1021/ja4033956

Peter Rayner

Contact details

Dr Peter Rayner
Research associate
Centre for Hyperpolarisation in Magnetic Resonance
University of York
YO10 5NY

Tel: 01904 328890