Fluorine as a stereoelectronic tool in the design of performance organic compounds

The lecture will explore the strategic incorporation of fluorine into organic

molecules in order to exploit the polarity of the C–F bond to advantage.

Recent examples from the lab will be discussed extending from the design of

enzyme inhibitors, perfumes (musk lactones) and the synthesis and properties

of facially polarised cyclohexanes, where all the fluorine are pointing 'up' to

generate the most polar aliphatic rings known so far.