RSC Centenary Lecture: Estrogens and Estrogen Receptors: Structure, Function, Ligand Discovery and In Vivo Imaging

John Katzenellenbogen is one of the world's leading authorities in  steroid chemistry.  In many ways, he is the quintessential chemical biologist - developing chemical insights and tools to answer questions in biology.  But his work has had much broader impact.  His design of  isoform selective ligands has provided the tools to tease out the biological function of different nuclear receptors, with profound impact on our understanding of some disease processes.  More recently, he has taken this expertise into the development of selective diagnostic imaging agents.

In this lecture, John will provide a broad overview of his work across these different areas, with something for everyone - chemists, biologists, pharmacologists and medics.  It promises to be an excellent example of the impact chemistry can have on biology, our understanding of disease processes and the tools available to medicine.