Keith is Honorary Professor at the Centre for Health Economics at the University of York, and Partner & Director at Visible Analytics. Prior to this he was Professor of Medical Statistics in the Department of Health Sciences at the University of Leicester, where he led the Biostatistics Research Group. His research interests, for which he has an international reputation, are primarily concerned with the development, evaluation and application of (often Bayesian) statistical methods in Health Technology Assessment (HTA), in particular regarding clinical trials, evidence synthesis, Real World Evidence (RWE) and the development of natural history models (especially for rare and/or complex conditions), and in Health Data Science, in particular the analysis of data obtained from large-scale linked electronic health records and digital technology-enabled data-capture. His programme of methods-focused research has been extensively supported by ESRC, EU, HDR UK, MRC, NIHR and the pharmaceutical & medical devices industry.
Keith has been extensively involved with the UK National Institute for Health Research (NIHR) HTA Programme and UK National Institute for Health and Care Excellence (NICE) appraisal process since their inception. He was a member of the NICE Technology Appraisals Committee for over 8 years and is currently a member of the NICE Diagnostics Advisory Committee, as well as being a member of the NICE Decision Support Unit and NICE Technical Support Unit. He has acted as a consultant to the NICE Scientific Advice Programme, NICE International, and is a NIHR Senior Investigator Emeritus.
Keith is also is a Fellow of the Royal Statistical Society, and a Chartered Statistician. He has published widely in both substantive and methodological areas including co-authoring books on Methods for Meta-Analysis in Medical Research, Bayesian Approaches to Clinical Trials and Healthcare Evaluation, and Evidence Synthesis for Decision Making in Healthcare, in addition to co-editing one of the first texts on Methods for Evidence-based Healthcare.