Andrea Manca



Andrea is Professor of Health Economics in the Team for Economic Evaluation and Health Technology Assessment, part of the Centre for Health Economics.  He is co-editor of the journals Value in Health and PLOS One.  Andrea’s research interests focus on the application of statistical methods for the analysis of cost‑effectiveness and health outcomes data, as well as the use of evidence synthesis techniques for healthcare decision making.  He has evaluated health technologies in several clinical areas including breast and advanced colorectal cancer, endovascular aneurysm repair, coronary revascularisation, diabetes, neck and chronic low back pain, surgical interventions for urinary stress incontinence, and hysterectomy. 

Andrea holds an MSc in Health Economics (1998) and a PhD in Economics (2005), both awarded by the University of York.  In 2007 he completed a post‑doctoral Research and Training Fellowship in Health Services Research awarded by The Wellcome Trust, to investigate the use of statistical methods for the analysis of multicentre and multinational individual patient‑level cost‑effectiveness data, where the objective is to inform reimbursement decisions in different jurisdictions.  As part of his Fellowship, Andrea spent a six‑month research visiting period at the Institute for Clinical Evaluative Sciences in Toronto (Ontario, Canada).   

His work on the analysis of multinational cost-effectiveness data received the ISPOR 2008 Research Excellence Award for Methodology. 

In 2009 Andrea was awarded a Career Development Fellowship funded by the National Institute for Health Research (NIHR) titled “Developing economic evaluation methods for decision making: the value of access to individual patient data”.   

Andrea is currently a member of the NICE Technology Appraisal Committee, the National Institute of Health Research (NIHR) Programme Grants for Applied Research funding sub-panel, and the National Awareness and Early Diagnosis (NAEDI) Research Workstream scientific committee of the Cancer Research-UK.      



  • Statistical methods for the analysis of individual patient-level data
  • Quantitative evidence synthesis for health care decision-making
  • Regression methods for the analysis of health-related quality of life data
  • Bayesian methods in health care evaluation
  • Multilevel (hierarchical) modelling

Research group(s)


  • Health Foundation
    Exploring and quantifying preferences towards self-management support interventions: a mixed-methods survey among individuals with long term health conditions (2014-2015)
  • MRC/NIHR Methodology
    Methods of extrapolating RCT evidence for use in economic evaluation models (2010-2012)
  • NIHR
    Career Development Fellowship (2010-2013)
  • European Union EuroVaQ
    European Value of a Quality Adjusted Life Year (lead:Newcastle University,UK)
  • MRC
    MSc +PhDCapacityBuildingGrant (2008-2012)
  • NIHR
    Spinal cord stimulation in refractory angina (pilot study)


Past PhD students supervised by Andrea Manca


Other teaching

 Centre for Health Economics 

  • The York Regression Methods for Health Economic Evaluation - Course leader and faculty
  • The York Expert Workshops in the Socio Economic Evaluation of Medicines - Faculty and tutor
  • Advanced Modelling Methods for Health Economic Evaluation - Tutor

External activities


  • NIHR Research Fellowship Programme 
    Doctoral Research Fellowships panel member
  • UK Health Economics Study Group 
  • International Health Economics Association
  • Italian Health Economics Association
  • International Society for Pharmacoeconomics and Outcomes Research (ISPOR)
  • NIHR – Programme Grant for Applied Research
  • CRUK - National Awareness and Early Diagnosis Research Workstream
    committee member
  • National Institute for Health and Clinical Excellence
    Member of the Technology Appraisal Committee
  • MOMENT study - (NIHR HTA)
    member of the Trial Steering Committee
  • Treatment of Back Pain (NIHR Programme Grant)
    member of the Study Oversight Committee

Editorial duties

Invited talks and conferences

  • Health Technology Assessment
    Drug Information Agency (DiA), Zurich (Switzerland), November 2012
  • Maximising the value of access to individual patient level data for decision making
    Key note speech, Danish Health Econometrics Network meeting, Aalborg (Denmark) - November 2012
  • The use of pharmacoeconomics to inform healthcare spending rationing decisions
    The University of Turin (Italy)
  • Developing economic evaluation methods: assessing the value of access to individual patient level data
    Erasmus University (The Netherlands)
    University of Amsterdam (The Netherlands)
    University of Maastricht (The Netherlands)
  • NICE and the role of economic evaluation in the UK HTA process
    Catholic University of Chile (Chile), August 2010
  • Methods to calculate medical costs in Europe: mission impossible?
    International Workshop "Combining Epidemiology and Economics for Measurement of Cancer Costs", Rome (Italy) September 2010
  • Regression estimators for (health related) quality of life and QALYs ScHARR
    Health Economics and Decision Science, University of Sheffield
  • Multilevel modelling in health economic evaluation: what it is and what it can do for you
    Academic Unit of Health Economics, University of Leeds
  • Healthcare cost-effectiveness analysis: Why? Which? What? – A NICE example
    Food and Environmental Research Agency, York
  • A bridge over the troubled water: integrating individual patient-level data analysis and comprehensive decision analytic cost-effectiveness modelling
    iBMG & iMTA, Erasmus University, Rotterdam, The Netherland
  • Fragile - handle with care!   Issues in the long-term term extrapolation of individual patient level data for cost-effectiveness modelling
    MRC Clinical Trial Unit, London



Staff Photo for Andrea Manca

Contact details

Andrea Manca
Professor of Health Economics
Centre for Health Economics