Meta-analysis of multiple outcomes: are we using all the evidence?

Thursday 21 November 2019, 12.15PM to 1.15pm

Speaker(s): Prof. Sofia Dias, CRD, University of York

Abstract: Meta-analyses are typically used to synthesise evidence from multiple studies, in order to decide which treatment is most effective or cost-effective, out of several alternatives. Often, several measures are used to assess patients’ response to treatment (outcomes) and it is not unusual for randomised trials to report more than one outcome of interest. Separate analyses of each outcome, each typically using different sets of randomised controlled trials, is inefficient and can lead to conflicting conclusions.

Using a joint model for all the outcomes, and adequately incorporating what is known about the relationships between different relative effects, is therefore essential for making decisions based on multiple outcomes and should be incorporated in the standard evidence synthesis framework.

Models incorporating within-trial correlations and outcome relationships, based on what is known from the data generating process, will be presented for some key examples. Although different applications will have different types of evidence structure, and may require bespoke models, it is often possible to incorporate known relationships in trial outcomes into a Bayesian modelling framework.

Implications of this framework for the usual process of systematic review, meta-analysis and economic modelling will also be discussed.

Location: Alcuin A Block, Room A019/020

Who to contact

For more information on these seminars, contact:

Thomas Patton
Dina Jankovic

If you are not a member of University of York staff and are interested in attending a seminar, please contact so that we can ensure we have sufficient space

Economic evaluation seminar dates

  • Thursday 21 November
    Sofia Dias, CRD, University of York
  • Thursday 12 December
    Professor John Brazier and Dr Tessa Peasgood
    School of Health and Related Research (ScHARR), University of Sheffield
  • Thursday 16 January
    Simon McNamara, University of Sheffield
  • Thursday 20 February
    Belen Corbacho, University of York