Accounting for capacity constraints in economic evaluations of precision medicine using value of implementation methods

Abstract: Precision medicine involves the use of a stratifying mechanism such as a test or predictive algorithm to better target healthcare interventions to those who will benefit most. Due to these interacting components, all examples of precision medicine are complex interventions and are likely to face significant barriers to their implementation in clinical practice. Such barriers, including capacity constraints in the health system, may impact the cost-effectiveness of the intervention but are rarely accounted for in economic evaluations. Value of implementation methods offer a potential way to quantify the impact of capacity constraints on the number of patients receiving an intervention, the net benefit per patient, and the total net benefit to society.

In this seminar I will present work from my PhD showing how capacity constraints can be identified, incorporated into an economic model, and their impact quantified using value of implementation methods. I will also show how investments in capacity could also be valued using value of implementation analysis and discuss the potential limitations of the method and areas for further research.

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https://york-ac-uk.zoom.us/j/97405985990?pwd=R2VZS0J4SC9vYkFZK1VYY2FnVmtLdz09

Meeting ID: 974 0598 5990
Passcode: 611184