Adjusting for treatment switching in randomised controlled trials

Thursday 8 February 2018, 2.00PM3.15pm

Speaker(s): Nicholas Latimer, ScHARR, University of Sheffield

Abstract: Estimates of the overall survival benefit of new cancer treatments are often confounded by treatment switching in randomised controlled trials (RCTs). For Health Technology Assessment (HTA) estimates of the unconfounded overall survival benefit associated with new treatments are needed. Several switching adjustment methods have been advocated in the literature, some of which have been used in HTA, but all make strong assumptions that are not possible to test perfectly. In addition, each of these methods can be applied in a multitude of ways and seemingly innocuous choices around how a particular method is applied can importantly affect the results they produce. In this talk I will introduce the adjustment methods and will focus on key application decisions to watch out for when undertaking or assessing adjustment analyses.

Location: ARRC Auditorium A/RC/014

Adjusting for treatment switching in randomised controlled trials from cheweb1

Who to contact

For more information on these seminars, contact:

Maria Jose Aragon
Jessica Ochalek

CHE Seminar Programme

  • Tuesday 2 October
    Annika Herr, DICE, Heinrich Heine University
  • Thursday 4 October
    Josh Carlson, University of Washington 
  • Thursday 8 November 
    Carol Propper, Imperial College London
  • Thursday 6 December
    Professor Joanna Coast, University of Bristol