David Sanin Pena
PhD student

Profile

Career

Centre for Immunology and Infection
PhD student

Research

Overview

The research group I belong to investigates the innate immune responses of mammals when they are infected with Schistosoma mansoni, one of the three parasites that cause schistosomiasis.

My project investigates the effects of the parasite’s cercarial secretions on macrophages through the study of signalling pathways related to alternative activation and phagosome maturation. By stimulating naïve macrophages with the secretions and then identifying activated regulatory molecules, the project aims to increase our understanding of the initial host-parasite interaction.

Additionally, by fractionating the secretions, and employing proteomics and glycomics, the work aims to identify some of the components of those secretions and link them to the responses they cause on macrophages.

Research group(s)

Mountford Research Group (Immunology)
PhD student

Publications

Full publications list

Jonathan S. Ward, Jason M. Lynam, James W. B. Moir, David E. Sanin, Adrian P. Mountford and Ian J. S. Fairlamb. (2012) A therapeutically viable photo-activated manganese-based CO-releasing molecule (photo-CO-RM). Dalton Trans., 2012,41, 10514-10517.
Eva Martincová, Luboš Voleman, Vladimíra Najdrová, Maximiliano De Napoli, Shiri Eshar, Melisa Gualdron, Christine S. Hopp, David E. Sanin, Dumizulu L. Tembo, Daria Van Tyne, Dawn Walker, Michaela Marcinčiková, Jan Tachezy, Pavel Doležal (2012) Live Imaging of Mitosomes and Hydrogenosomes by HaloTag Technology. PLoS ONE 7(4): e36314.
Stéphanie Ferret-Bernard, William Castro-Borges, Adam A. Dowle, David E. Sanin, Peter C. Cook, Joseph D. Turner, Andrew S. MacDonald, Jerry R. Thomas, Adrian P. Mountford. (2012) Plasma membrane proteomes of differentially matured dendritic cells identified by LC–MS/MS combined with iTRAQ labelling. Journal of Proteomics 75(3): 938-948.

Centre for Immunology and Infection

David Sanin Pena PhD student