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|2012 -||Reader||Department of Biology, University of York|
|2005 - 2012||Senior Lecturer||Department of Biology, University of York|
|2002 - 2005||Lecturer||Department of Biology, University of York|
|1999 - 2002||Wellcome Trust University Research Fellow||Department of Biology, University of York|
|1995 - 1999||Wellcome Trust Research Development Fellow||Department of Biology, University of York (with sabbatical at Imperial College, London)|
|1989 - 1994||Post Doctoral research||Department of Biology, University of York|
|1988||DPhil||University of York|
|1984||BSc Hons||University of Nottingham|
Immune hypo-responsiveness caused by helminth infection of the skin (20011-2013)
The role of helminth molecules in regulating the immune response (for 2012 - 13)
The innate immune response is believed to have a very important instructional effect upon the development and type of acquired immune response in infected hosts. In turn, we have recently discovered molecules from a parasitic helminth that down-regulate activation of the innate immune response. This project seeks to identify both the molecules from larval schistosomes (by chemical fractionation) which stimulate innate immune cells (e.g. dendritic cells and macrophages) and their receptors (Toll-like receptors, C-type lectins etc), in order to identify ligand-receptor binding connections that promote the development of Th1- or Th2-type acquired immune responses, or immune modulation. A combination of molecular (microarrays, QPCR), and cellular (flow cytometry, real time imaging, immunohistochemistry) approaches will be employed to identify receptors on host cells and changes in the profile of cytokine and cofactor expression by in stimulated cells obtained ex vivo. The project will also examine the changes in cytokine and receptor expression by in vitro-cultured accessory cells and transfected cell lines, stimulated with fractionated parasite molecules. The identified ligands then will be used to immunise experimental hosts to boost protective immunity, or reduce pathology caused by schistosome infection. No description.
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For application requirements, process, and guidelines please see the postgraduate study pages of the Department of Biology website (http://www.york.ac.uk/biology/postgraduate/). New available studentships are announced on these web pages, the Departmental site and on FindAPhD.
Ward, J.S., Lynam, J.M., Moir, J.W.B., Sanin, D.E., Mountford, A.P. and Fairlamb, I.J.S. (2012) A therapeutically viable photo-activated manganese-based CO-releasing molecule (photo-CO-RM). Dalton Trans., 2012,41, 10514-10517.
Ferret-Bernard, S., Castro-Borges, W., Dowle, A.D., Sanin, D.E., Cook, P.C., Turner, J.D., MacDonald, A.S., Thomas, J.R. and Mountford, A.P. (2012). Plasma membrane proteomes of differentially matured dendritic cells identified by LC-MS/MS combined with iTRAQ labelling. Journal of Proteomics; 75, 938-948.
Paveley, R.A., Aynsley, S.A., Turner, J.D., Bourke, C.D., Jenkins, S.J., Cook, P.C., Martinez-Pomares, L., and Mountford, A.P. (2011) The Mannose Receptor (CD206) is an important pattern recognition receptor in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production. International Journal of Parasitology 41, 1335-1345.
Meurs, L.,Labuda, L., Amoah, A.S., Mbow, M., Ngoa, U.A.,Boakye, D.A., Mboup, S., Dièye, T.N., Mountford, A.P., Turner, J.D., Kremsner, P.G., Polman, K., Yazdanbakhsh, M., and Adegnika, A.A. (2011) Enhanced pro-inflammatory cytokine responses following Toll-Like-Receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon. PLoS One 6, 9 e24393.
Turner, J.D., Jenkins, G.R., Hogg, K.G., Aynsley, S.A., Paveley, R.A., Cook, P.C., Coles, M.C., and Mountford, A. P. (2011) CD4+CD25+ cells regulate colonic Th2 granulomatous pathology caused by schistosome infection. PLoS Neglected Tropical Diseases 5, 8 e1269
Cook, P.C., Aynsley, S.A., Turner, J.T., Jenkins, G.R. an Rooijen, N. Leeto, M., Brombacher, F., and Mountford, A. P. (2011). Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathogens 7, 3, e1001323
Caillon, F., Eady, E.A., O’Connell, M., Jenkins, G.R., Cove, J.H., Layton, A.M., and Mountford, A.P. (2010) IL-10 secretion by CD14+ peripheral blood mononuclear cells induced by Propionibacterium acnes is down regulated in patients with acne vulgaris. British Journal of Dermatology 162, 296-303.
Paveley, R.A, Aynsley, S.A., Cook, P.C., Turner, J.D., and Mountford, A.P. (2009) Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells. PLoS Neglected Tropical Diseases 3, e528
Ferret-Bernard, S. F. Curwen, R.S, and Mountford, A. P. (2008) Proteomic profiling of Th2 inducing dendritic cells stimulated with helminth products. Proteomics 8: 980-993.
Kumkate, S., Jenkins, G.R., Paveley, R.A., Hogg, K.G. and Mountford, A. P. (2007) CD207+ Langerhan’s cells migrate to the draining lymph nodes after exposure to Schistosoma mansoni but they are not the major antigen presenting cell population. International Journal of Parasitology 37: 209-220.
Hewitson, J.P., Hamblin, P.A. and Mountford, A.P. (2007) In the absence of CD154, administration of IL-12 restores Th1 responses but not protective immunity to Schistosoma mansoni. Infection and Immunity 75: 3539-3547.
Hewitson, J.P., Jenkins, G.R., Hamblin, P.A. and Mountford, A.P. (2006) CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFNg but not IL-4. Journal of Immunology 177: 3209-3217.
Jenkins, S.J and Mountford, A.P. (2005) Dendritic cells activated with products released by schistosome larvae drive Th2-type responses that can be inhibited by manipulation of CD40 costimulation. Infection and Immunity 73: 395
Jenkins, S.J. Hewitson, J.P. Ferret-Bernard, S. and Mountford, A.P. (2005) Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and independent pathways. International Immunology 17: 1409-1418.
Jenkins, S.J. Hewitson, J.P. Jenkins, G.R and Mountford, A.P. (2005) Modulation of the host’s immune response by schistosome larvae. Parasite Immunology 27: 385-393.