Chemokines and leukocyte and stem cell trafficking in inflammation

Wednesday 5 December 2012, 12.15PM

Speaker: Professor Jim Middleton, University of Bristol

Abstract

Chemokines are involved in driving leukocyte migration in inflammatory diseases. These mediators are presented by endothelial cells resulting in leukocyte migration from the blood into the affected tissues. We've been examining this presentation mechanism in rheumatoid arthritis and the receptors involved. Since mesenchymal stem cells also show evidence of trafficking into inflamed tissues, where they may aid repair or be immunomodulatory, we have been examining the chemokines and their receptors that may drive their transendothelial migration.

Host: Professor Natalie Signoret and Dr James Fox

Location: Biology, Q014

Email: cii@york.ac.uk

Telephone: 01904 328876