Computation and Polymer Synthesis for Complex Cellular Behaviour and Challenges Ahead

Monday 9 February 2015, 1.00PM

Speaker(s): Prof Natalo Krasnogor, University of Newcastle

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signaling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level.  In this talk I will summarise our work on the utilisation of computational modelling for the design of synthetic polymers affecting QS phenotypes and, , time permitting, the combinatorial DNA library design tool (DNALD) as well as explore some of the challenges ahead.

Location: PL005