Accessibility statement

Proximal Fracture of the Humerus: Evaluation by Randomisation

The Proximal Fracture of the Humerus: Evaluation by Randomisation (ProFHER) trial is a multicentre, pragmatic randomised controlled trial that aims to obtain reliable evidence of the effectiveness and cost-effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults. Proximal humeral fractures account for approximately 4-5% of all fractures. Their incidence rapidly increases with age, and women are affected over twice as often as men. Similar to other primarily osteoporotic fractures, the incidence of these fractures is increasing.

There is considerable variation in the treatment of these fractures, which often have an unsatisfactory outcome. In particular, there is a lack of reliable evidence to inform the fundamental question of whether displaced proximal humeral fractures should be treated surgically. This is the basis of the ProFHER trial. The ProFHER trial is funded by the Department of Health's Health Technology Assessment (HTA) Programme. It is a joint collaboration between Teesside University (trial sponsor) and the University of York (trial management).


Funder: HTA
Start date: 1/04/08
End date: 31/07/16

Trials and Statistics Research in the Department of Health Sciences

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