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A Randomised Controlled Trial of the Effect of a Two-layer Compression Bandage System on Knee Function Following Total Knee Arthroplasty (KReBS)

Total knee arthroplasty is a common and highly successful operation in the management of osteoarthritis. However, post-operative knee swelling is a common problem and results in decreased functional performance as a result of quadriceps weakness and arthrogenic reflex inhibition due to pain. This can delay rehabilitation, increase hospital length of stay and decrease patient reported outcomes.

Compression bandage therapy is an established treatment of venous ulcers and lymphoedema. It is hypothesised that the application of this external compression aids venous return and reduces hydrostatic pressure in the leg, subsequently allowing movement of fluid from the interstitial space. The use of inelastic bandages are preferred in arthroplasty as they have a low, tolerable resting pressure but a more effective activation of the deep venous system and calf muscle pump with ambulation compared to their elastic counterparts.

The use of compression bandages in elective orthopaedic knee surgery is well regarded, however, there is a lack of robust, well-designed trials to support this.

The aim is to conduct a multi-centre randomised controlled trial comparing the use of a two-layer compression bandage worn post-operatively for up to 48 hours after elective total knee replacement, compared to standard practice (non-compressive bandaging).

The study aims to test the hypothesis that the use of a two-layer compression bandage system improves function compared to standard wool and crepe bandage, following total knee replacement.

Patients will be approached to take part from participating hospitals and those who agree to be included in this trial will be allocated at random to either of the two treatments. The study aims to randomise 2600 patients in total (1300 patients in each arm).

Outcome will be assessed using a patient self-reported questionnaire which measures knee pain and function after one year.

The associated costs of both treatments to the NHS will also be evaluated.

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3M Healthcare 
Start Date: February 2017
End Date: January 2019


KReBS is a joint collaboration between the Northumbria Healthcare NHS Foundation Trust (trial sponsor) and the University of York (trial management, statistics and health economics).

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External Collaborators



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