In addition to the currently active trials, we also provide information and/or conclusions for trials or studies which have now finished.
The aim of this study is to build upon previous research to develop a manualised Social Stories intervention for use with children with Autism Spectrum Disorder (ASD) in mainstream schools that has the effect of reducing challenging behaviour.
A home-visiting programme especially designed for young, first-time parents and their children living in areas of socio-economic deprivation.
This project will evaluate the Improving Writing Quality intervention being delivered and supported by the Calderdale Excellence Partnership in 2013. The intervention provides memorable experiences for participating pupils and includes professional development for teachers in key elements of the writing intervention Self-Regulated Strategy Development (SRSD), including discussion, modelling and planning.
This project will evaluate the use of a four week summer workshop being delivered and supported by the Discover Children's Story Centre in 2013.
The evaluation will assess the impact, primarily on pupils’ GCSE grades, of improving sleep through sleep education and introducing a later school day for GCSE students. It is anticipated that allowing teenagers to engage in learning when their biological systems are optimised to do so will improve academic performance.
The Education Endowment Foundation has funded the University of York and Durham University to evaluate the Online Maths Tuition intervention being delivered by Third Space Learning (TSL) and supported by Nesta between 2014 and 2016.
This project will evaluate the Grammar for Writing intervention being delivered and supported by the University of Exeter in 2013. The intervention will be a modified version of an existing grammar intervention aimed at improving writing skills in older children.
An outdoor playground based physical activity programme which aims to increase physical activity in children.
AVURT is a Phase II trial which compares aspirin vs placebo for the treatment of venous leg ulcers.
The study is led by Mr Robert Hinchliffe at St George’s University of London and is co-ordinated by researchers at the University of York’s Trials Unit.
BreatheMOR-HF is a large multi-centre study which looks at whether prescribing slow release daily morphine tablets to individuals with heart failure helps with breathlessness.
Aims to identify the most effective case-finding tool for COPD in the primary care setting, and also to evaluate the impact of receiving lung function tests on smoking behaviour
Verrucae are extremely common, and are experienced by most people at some time during their lives. Although most verrucae will spontaneously disappear without treatment, many patients seek treatment, often because they have persisted for many years, are unsightly or painful or have prevented them from doing sports or other activities. There are many different treatments available but there is little good quality evidence to tell us which is the most effective treatment.
Seeks to address the uncertainties surrounding home oxygen therapy for patients with chronic heart failure who are still severely symptomatic despite maximally tolerated medical therapy.
A detailed understanding of the barriers and facilitators to the uptake of the childhood and adult vaccines and ideas for interventions to increase uptake, for six Traveller communities in four UK cities.
A clustered, randomised, controlled pilot trial of 'Smoke Free Homes' delivered in Islamic religious settings.
A programme to design, develop and evaluate approaches to engage patients to protect against unintended harm.
Aims to obtain reliable evidence of the effectiveness and cost-effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults.
Interventions to increase cervical screening uptake at first invitation in young women.
Development and piloting of a pragmatic structured education programme that promotes self-managed walking exercise in patients with intermittent claudication.
The primary objective of the VenUS IV study was to compare the clinical and cost effectiveness of compression hosiery compared with 4-layer compression bandaging in terms of ulcer healing and quality of life.
Wounds resulting from surgical operations are common and most will heal by primary intention (where the edges of the surgical incision are held together e.g. by stitches). However, many surgical wounds must heal by secondary intention (the wound is left open, often forming a cavity, and heals “from the bottom up”).
This programme aims to optimise the quality of care and outcomes for people with open surgical wounds by:
ARiAS research programme aims to investigate methods of improving the physical and mental health of people with alcohol and/or illicit drug problems who are identified within an acute hospital setting.
The UK's largest ever study into the integrated primary care of older people with depression
Explores the potential of cCBT amongst an adolescent population, an area which has an extensive evidence base among adult populations but limited evidence supporting its use among teenagers.
A mixed methods project with six complementary phases which aims to: i) develop an evidence based psychosocial intervention to reduce transmission risks among people who inject drugs at risk of acquiring or transmitting blood borne viruses and; ii) conduct a feasibility randomised controlled trial of the intervention.
Depression is a major health problem. The majority of people with depression receive care from their GP. However, lots of people experiencing depression would also like to receive a "talking treatment" (counselling or psychotherapy). Cognitive Behaviour Therapy (CBT) seems to be the most effective type of talking treatment for depression but is not always immediately available in the NHS due to lack of therapist resources. More recently, a form of CBT has been developed that can be delivered by a computer (computerised CBT), which might make it easier to access this form of treatment.
Researchers from the Department of Health Sciences in collaboration with colleagues from the School of Psychology, University of Birmingham and Birmingham and Solihull Mental Health Foundation Trust aim to adapt an evidence-based family and social network intervention for substance-related problems to the youth context.
Aims to determine the effectiveness of hydroxychloroquine as a treatment for hand osteoarthritis.
People with neuromuscular and central nervous system conditions can experience knee instability, which may be treated using callipers or splints, known as ‘orthotic devices’. Very little is known about the effectiveness of these devices, how often they are used, how much they cost the UK NHS or what patients think about them. This study aimed to investigate these knowledge gaps.
Aims to find out if a newly developed package of care delivered by a podiatrist can improve balance and reduce the number of falls older people have.