Completed Trials

In addition to the currently active trials, we also provide information and/or conclusions for trials or studies which have now finished.

Education

Autism Spectrum Social Stories in Schools Trial (ASSSIST)

The aim of this study is to build upon previous research to develop a manualised Social Stories intervention for use with children with Autism Spectrum Disorder (ASD) in mainstream schools that has the effect of reducing challenging behaviour.

Link to project

Building Blocks

A home-visiting programme especially designed for young, first-time parents and their children living in areas of socio-economic deprivation.

Link to project

Independent Evaluation of Calderdale Excellence Partnership's Improving Writing Quality Programme

This project will evaluate the Improving Writing Quality intervention being delivered and supported by the Calderdale Excellence Partnership in 2013.  The intervention provides memorable experiences for participating pupils and includes professional development for teachers in key elements of the writing intervention Self-Regulated Strategy Development (SRSD), including discussion, modelling and planning.

Link to project.

Independent Evaluation of the Discover Children's Story Centre Summer Writing Programme

This project will evaluate the use of a four week summer workshop being delivered and supported by the Discover Children's Story Centre in 2013.

Link to project.

Independent Evaluation of Project Teensleep: A Factorial Cluster Randomised Controlled Trial

The evaluation will assess the impact, primarily on pupils’ GCSE grades, of improving sleep through sleep education and introducing a later school day for GCSE students. It is anticipated that allowing teenagers to engage in learning when their biological systems are optimised to do so will improve academic performance. 

More information.

Independent Evaluation of the Third Space Learning’s Online Maths Tuition Service – A cluster randomised controlled trial

The Education Endowment Foundation has funded the University of York and Durham University to evaluate the Online Maths Tuition intervention being delivered by Third Space Learning (TSL) and supported by Nesta between 2014 and 2016.

Link to project.

Independent Evaluation of University of Exeter's Grammar for Writing Programme

This project will evaluate the Grammar for Writing intervention being delivered and supported by the University of Exeter in 2013.  The intervention will be a modified version of an existing grammar intervention aimed at improving writing skills in older children.

Link to project.

Pre-schoolers in the Playground (PIP)

An outdoor playground based physical activity programme which aims to increase physical activity in children.

Link to project

Health Promotion

AVURT: Aspirin for venous ulcers randomised trial

AVURT is a Phase II trial which compares aspirin vs placebo for the treatment of venous leg ulcers.

The study is led by Mr Robert Hinchliffe at St George’s University of London and is co-ordinated by researchers at the University of York’s Trials Unit.

More information

BreatheMOR-HF

BreatheMOR-HF is a large multi-centre study which looks at whether prescribing slow release daily morphine tablets to individuals with heart failure helps with breathlessness.

Link to project

Determining Optimal approach to identifying individuals with Chronic obstructive pulmonary disease (DOC)

Aims to identify the most effective case-finding tool for COPD in the primary care setting, and also to evaluate the impact of receiving lung function tests on smoking behaviour

Link to project

EVerT2- Effective Verruca Treatments

Verrucae are extremely common, and are experienced by most people at some time during their lives. Although most verrucae will spontaneously disappear without treatment, many patients seek treatment, often because they have persisted for many years, are unsightly or painful or have prevented them from doing sports or other activities. There are many different treatments available but there is little good quality evidence to tell us which is the most effective treatment.

Link to project

Home Oxygen Therapy (HOT)

Seeks to address the uncertainties surrounding home oxygen therapy for patients with chronic heart failure who are still severely symptomatic despite maximally tolerated medical therapy.

Link to project

Understanding the barriers and facilitators to immunisation uptake in Traveller communities to inform interventions to promote uptake (UNITING)

A detailed understanding of the barriers and facilitators to the uptake of the childhood and adult vaccines and ideas for interventions to increase uptake, for six Traveller communities in four UK cities.

Link to project.

Muslim Communities Learning About Second-hand Smoke (MCLASS)

A clustered, randomised, controlled pilot trial of 'Smoke Free Homes' delivered in Islamic religious settings.

Link to project

Patient Involvement in Patient Safety

A programme to design, develop and evaluate approaches to engage patients to protect against unintended harm.

Link to project

Proximal Fracture of the Humerus: Evaluation by Randomisation (ProFHER)

Aims to obtain reliable evidence of the effectiveness and cost-effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults.

More information

Interventions to increase cervical screening uptake at first invitation in young women (STRATEGIC)

Interventions to increase cervical screening uptake at first invitation in young women.

Link to project

SEDRIC - Structured EDucation for Rehabilitation in Intermittent Claudication

Development and piloting of a pragmatic structured education programme that promotes self-managed walking exercise in patients with intermittent claudication.

Link to project.

VenUS IV

The primary objective of the VenUS IV study was to compare the clinical and cost effectiveness of compression hosiery compared with 4-layer compression bandaging in terms of ulcer healing and quality of life. 

Link to project.

Open surgical wounds: describing the problem and identifying effective treatments

Wounds resulting from surgical operations are common and most will heal by primary intention (where the edges of the surgical incision are held together e.g. by stitches). However, many surgical wounds must heal by secondary intention (the wound is left open, often forming a cavity, and heals “from the bottom up”). 

This programme aims to optimise the quality of care and outcomes for people with open surgical wounds by:

  • describing the number, characteristics, current treatments, impact and health outcomes of people with open surgical wounds
  • utilising all available research data to estimate the cost effectiveness of current treatments for open surgical wounds
  • determining the impact of SWHSI on patients and the most relevant patient- and NHS-relevant outcomes for measuring the effects of treatments on open surgical wounds
  • assessing whether investment in future research on treatments for open surgical wounds is likely to be worthwhile, and if so, what research offers the best ‘value for money’
  • determining the feasibility of conducting further primary research on open surgical wounds.

More information

Mental Health and Addiction

Addiction Research in Acute Settings (ARiAS)

ARiAS research programme aims to investigate methods of improving the physical and mental health of people with alcohol and/or illicit drug problems who are identified within an acute hospital setting.

Link to project

CollAborative care in Screen-Positive EldeRs (CASPER)

The UK's largest ever study into the integrated primary care of older people with depression

Link to project

Computerised cognitive behavioural therapy (cCBT)

Explores the potential of cCBT amongst an adolescent population, an area which has an extensive evidence base among adult populations but limited evidence supporting its use among teenagers.

Link to project

Preventing blood borne virus infection in people who inject drugs in the UK

A mixed methods project with six complementary phases which aims to: i) develop an evidence based psychosocial intervention to reduce transmission risks among people who inject drugs at risk of acquiring or transmitting blood borne viruses and; ii) conduct a feasibility randomised controlled trial of the intervention.

More information

The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT

Depression is a major health problem. The majority of people with depression receive care from their GP. However, lots of people experiencing depression would also like to receive a "talking treatment" (counselling or psychotherapy). Cognitive Behaviour Therapy (CBT) seems to be the most effective type of talking treatment for depression but is not always immediately available in the NHS due to lack of therapist resources. More recently, a form of CBT has been developed that can be delivered by a computer (computerised CBT), which might make it easier to access this form of treatment.

Link to project.

Y-SBNT: Family and Social Network Intervention for Young People who Misuse Alcohol and Drugs

Researchers from the Department of Health Sciences in collaboration with colleagues from the School of Psychology, University of Birmingham and Birmingham and Solihull Mental Health Foundation Trust aim to adapt an evidence-based family and social network intervention for substance-related problems to the youth context. 

More information.

Musculoskeletal

Hydroxychloroquine Effectiveness in Reducing symptoms of hand Osteoarthritis (HERO)

Aims to determine the effectiveness of hydroxychloroquine as a treatment for hand osteoarthritis.

Link to project

Orthotic management of instability of the knee in neuromuscular disease (OKIS)

People with neuromuscular and central nervous system conditions can experience knee instability, which may be treated using callipers or splints, known as ‘orthotic devices’. Very little is known about the effectiveness of these devices, how often they are used, how much they cost the UK NHS or what patients think about them. This study aimed to investigate these knowledge gaps. 

A randomised study in elders falling (REFORM)

Aims to find out if a newly developed package of care delivered by a podiatrist can improve balance and reduce the number of falls older people have.

Link to project

Surgical Trials