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The UK FROST trial team are delighted to complete recruitment on time and thank our collaborators at participating hospitals for their enthusiasm and commitment to the study. UK FROST is a multi-centre randomised controlled trial comparing early structured physiotherapy with surgical interventions for patients referred to secondary care with a frozen shoulder. The study will be complete in June 2019.
Community screening for osteoporosis could prevent more than a quarter of hip fractures in older women, new research involving an academic from the University of York suggests.
Professor Catherine Hewitt and Dr Mona Kanaan attended a meeting on Current developments in cluster randomised trials and stepped wedge designs at Queen Mary University of London.
Dr Mona Kanaan is a co-applicant on a grant which has recently secured funding from the NIHR Programme Grants for Applied Research (PGfAR) Programme. The study will look at Tailoring evidence-based psychological therapY for People with common mental disorder including Psychotic EXperiences study (TYPPEX).
Dr Mona Kanaan was involved in a study that looked at secondhand smoke of primary school children in the capital of Bangladesh, Dhaka. The study found that 95% of the children surveyed had recently been exposed to secondhand smoke. The results of the study were published in Nicotine & Tobacco Research
The HTA report has now been published for Preventing blood-borne virus infection in people who inject drugs in the UK: systematic review, stakeholder interviews, psychosocial intervention development and feasibility randomised controlled trial
Dr Arabella Scantlebury presented with Inspector Bill Scott and Dr Nicola Moran at the Police Knowledge Fund Showcase conference in Coventry on: 'Co-producing a bespoke mental health training package for police officers: lessons learnt from the Connect trial.'
Belen Corbacho attended the 'Economic evaluation alongside surgical trials' meeting on Tuesday 21st November 2017 at St James Priory in Bristol. The objective of the meeting was to support further development of collaborative research and to have an open discussion about the practical and methodological issues that make the design, conduct and analysis of economic evaluation alongside surgical trials unique.
Professor David Torgerson, Dr Adwoa Parker and Dr Stephen Brealey have recently successfully secured a grant titled: "Developing a training intervention for staff to improve participant recruitment into randomised controlled trials". This is a Centre for Future Health Pump Priming Award from the University of York, via the Wellcome Trust, which has awarded £32,285.35 to develop and pilot test a training course for staff recruiting participants into RCTs. The findings will inform an application for a post-doctoral fellowship for Adwoa Parker.
The PROFHER trial team published a paper in the October 2017 edition of Bone & Joint Research - see http://bjr.boneandjoint.org.uk/content/6/10/590
PROFHER findings have had an impact on surgeons’ clinical practice, both through reducing the number of operations for patients with a fracture of the upper arm, and through underpinning existing non-operative practice. Dr Stephen Brealey, corresponding author, also featured in this month's edition of the journal.
Thirimon Moe Byrne has had a paper published on the NIHR journals library website, entitled 'Certolizumab pegol and secukinumab for treating active psoriatic arthritis following inadequate response to disease-modifying antirheumatic drugs: a systematic review and economic evaluation'. You can read it here.
The connect trial has had an article published in The Conversation discussing policing and mental health, entitled 'British police dealing with mental health is a sticking plaster solution that doesn't get to the heart of the problem'.
Belen Corbacho attended the AES (the Spanish Health Economics association) Conference in Barcelona on 6 -9 September 2017. At this conference she organised a panel session on how routine data could be used to improve health care, providing an overview on the use of HES records to conduct economic evauation alongside clinical trials. She also presented a poster on the implications of regional versus centralised HTA for the assessment of cancer drugs.
The twelfth annual RCTs Conference on the 6th, 7th and 8th September was a great success. Held at King's Manor, University of York with the conference dinner at Betty's Tea Rooms, it was a true reflection of 'lovely York' for those attending! The conference included a keynote address from Professor Frances Gardner, University of Oxford, invited speakers, presentations and a half day workshop. Over 50 delegates attended the conference, and it was nice to see familiar faces along with new attendees.
The results of the Connect trial, which evaluated the effectiveness of a mental health training package for frontline police officers have now been published in PLOS ONE.
The YTU team are currently opening more sites and these will aim to recruit a further 2100 patients over the next 6 months. KReBS is a randomised controlled trial investigating the effect of a two-layer compression bandage system on knee function following total knee replacement.
CPIT III is a large multi-centre trial which will determine the effectiveness and cost effectiveness of providing financial incentives, in the form of shopping vouchers, to pregnant smokers to engage with smoking cessation services and to quit smoking during and after pregnancy.
The trial is a collaboration with the University of Glasgow and University of Stirling. Joint CI's are Professor David Tappin and Professor Linda Bauld. The Trial Manager is Lesley Sinclair, University of Stirling. YTU staff involved in the project are Professor David Torgerson, Professor Catherine Hewitt, Dr Jude Watson, Ada Keding, Matthew Bailey and Helen Tilbrook. Management database development, follow-up phone calls to participants and voucher fulfillment have been outsourced to Echo Managed Services Limited who were involved in the pilot study (CPIT II).
The results of the OCTET Trial, conducted with support of York Trials Unit, have now been published. This trial was undertaken to assess the effectiveness of self help methods for treatment of Obsessive Compulsive Disorder.
Congratulations to Jennifer McCaffery who recently won the YUSU excellence award for the best Postgraduate who Teaches. This was in connection with Jennifer's previous role in the Psychology Department at the University.
Belen Corbacho has made a contribution to the June issue of the Journal of Trauma and Orthopaedics with her article 'The use of QALYs in the economic evaluation of orthopaedic treatments'
Publication ID: Heart. 2016 Jul 1;102(13):1009-16.
Professor David Torgerson, Dr Adwoa Parker, Izzy Coleman, Caroline Fairhurst, Illary Sbizzera and Catherine Arundel attended the International Clinical Trials Methodology Conference in Liverpool on 8th to 10th May 2017.
The Trials Unit Team are actively involved in trials methodology research and presented a range of different methodology concepts at the conference. These included:
Arabella Scantlebury and Alison Booth have had a paper published in the International Journal of Medical Informatics: Experiences, practices and barriers to accessing health information: a qualitative study. Scantlebury A., Booth A., Hanley B. 2017.
Catherine Arundel presented the results from the SWHSI Pilot Feasibility Trial at the Association of Sugeons of Great Britain and Ireland Conference. If you would like more information about the results please contact Catherine direct via email.
Alison Booth, along with collaborators, has had a paper published, entitled: 'Social prescribing: less rhetoric and more reality'. The paper discusses the advocations and implementation of social prescribing, and the evidence available to judge either the success or value for money of this.
A poster was presented of the SWHSI results at the Tissue Viability Society meeting in Birmingham. The poster was highly commended by the reviewing panel.
A new publication has been published for the REFORM study:
Cockayne, S, Fairhurst, C, Adamson, J, Hewitt, C, Hull, R, Hicks, K, Keenan, A-M, Lamb, SE, Green, L, McIntosh, C, Menz, HB, Redmond, AC, Rodgers, S, Torgerson, DJ, Vernon, W, Watson, J, Knapp, P, Rick, J, Bower, P, Eldridge, S, Madurasinghe, VW & Graffy, J 2017, 'An optimised patient information sheet did not significantly increase recruitment or retention in a falls prevention study: an embedded randomised recruitment trial' Trials, vol 18, no. 1, pp. 144. DOI: 10.1186/s13063-017-1797-7
York Trials Unit are pleased to report that we have randomised 117 participants for the OTIS study. These participants have been recruited from sites in Harrogate, Humber, Sheffield and Grimsby.
Sarah Cockayne from York Trials Unit, presented the NIHR PHR funded SSHeW trial - a study evaluating the effectiveness of slip resistant footwear to prevent slips, at the Cheshire and Wirral Partnership Research Conference on the 24th March 2017.
The results from the PROTECT feasibility study have been published in Harm Reduction Journal:
The acceptability and feasibility of a brief psychosocial intervention to reduce blood-borne virus risk behaviours among people who inject drugs: a randomised control feasibility trial of a psychosocial intervention (the PROTECT study) versus treatment as usual.
Gail Gilchris, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, John Strang, Avril Taylor and Judith Watson
Harm Reduction Journal201714:14 DOI: 10.1186/s12954-017-0142-5
Adwoa Parker and David Torgerson attended a Trial Forge workshop in Aberdeen on 23 March to discuss ways of taking forward more Studies Within A Trial (SWATs). Representation from York Trials Unit (YTU) at this meeting was particularly important because YTU undertakes and publishes the most SWATs of any UK trials unit.
York Trials Unit are pleased to report that recruitment to the SSHeW Trial has begun. Participants are being recruited from Cheshire and Wirral Partnership NHS Foundation Trust and from Leeds Teaching Hospitals NHS Trust in the pilot phase of this study.
A Randomised Controlled Trial of the Effect of a Two-layer Compression Bandage System on Knee Function Following Total Knee Arthroplasty (KReBS) is now open to recruitment and has randomised its first participant.
Professor David Torgerson presented at the Westminster Higher Education Forum Keynote seminar - Using the UK research base to support evidence-based policymaking entitled 'The case for greater use of Randomised Controlled Trials in policy making and the barriers to their use'
The ProFHER trial, managed by the York Trials Unit, compared surgery versus none surgery for treatment of adults with a broken bone of the upper arm. The findings published on 1 March 2017 in The Bone & Joint Journal confirm that the main findings of the study over two years are unchanged at five years which is that surgery is no better than a simple sling for treating this broken bone.
Will Eardley, Consultant Orthopaedic Trauma Surgeon and Research Associate, has recently completed recruitment as United Kingdom Chief Investigator for a multi-site longitudinal clinical study. Recruiting ahead of target the Bruin Biometric Evaluation of the SEM Scanner 200 for the detection of early pressure ulcers completed in January. This study investigates the use of detectors of change in skin condition far in advance of clinical signs in routine practice. Mr Eardley recruited hip fracture patients in Middlesbrough as a key element of the trial due to the inherent morbidity associated with this vulnerable population.
Arabella Scantlebury gave an oral presentation at the Society for Evidence Based Policing called 'A randomised controlled trial of a bespoke mental health training package for front-line officers'. This is part of the Connect project research streams.
The York Trials Unit will work with the Universities of Dundee and Sheffield on a £2million project to investigate ways of improving the oral health of young people living in deprived areas.
The researchers will work with 48 schools and nearly 6000 young people in Scotland, England and Wales on the four-year Brushing Reminder 4 Good Oral Health (BRIGHT) initiative.
BRIGHT, funded by the National Institute for Health Research (NIHR), will investigate whether a classroom-based lesson about dental health followed by a series of text messages could increase how often and how well children aged 11-16 brush their teeth – and ultimately reduce levels of tooth decay.
For further information click here.
The answer lies in the newly published report of a controlled trial of a demand led evidence briefing service for CCGs which has now been published in the Health Services and Delivery Research journal on the NIHR Journals Library website:
Wilson, P. M., Farley, K., Bickerdike, E. C., Booth, A. M., Chambers, D., Lambert, M., Thompson, C., Turner, R. & Watt, I. S. (2017). Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services: a controlled before-and-after study. Health Services and Delivery Research. 5, 5, p. 1-164 164 p.
The main results of the REFORM study have now been published in PLoS ONE
Cockayne S, Adamson J, Clarke A, Corbacho B, Fairhurst C, Green L, et al. (2017) Cohort Randomised Controlled Trial of a Multifaceted Podiatry Intervention for the Prevention of Falls in Older People (The REFORM Trial). PLoS ONE 12(1): e0168712. doi:10.1371/ journal.pone.0168712
Dr Rhian Gabe took part in the Prostate MRI study (PROMIS) which provides important evidence with respect to future recommendations for the diagnosis of prostate cancer. The study investigated the use of multi-parametric MRI before biopsy in men referred to hospital urology clinics with elevated levels of prostate-specific antigen (PSA). PSA is a protein produced by the prostate gland and increased levels of PSA are an early indicator of cancer cells being present. For further information click PROMIS study
Alison Booth is the new Methodology Editor on the British Journal of Radiology (BJR) Editorial Board; her role is to bring specific expertise in reviewing the methodology aspects of all systematic reviews that are submitted to the journal.
Professor David Torgerson was a member of a Dragon's Den panel for the British Orthopaedic and Trauma Society meeting.
Arabella Scantlebury has had two papers published this month:
Arabella Clarke, Ian Watt, Laura Sheard, John Wright, Joy Adamson; Implementing electronic records in NHS secondary care organizations in England: policy and progress since 1998. British Medical Bulletin 2017 1-12. doi: 10.1093/bmb/ldw055
Exploring the implementation of an electronic record into a maternity unit: a qualitative study using Normalisation Process Theory Arabella Scantlebury , Laura Sheard , Ian Watt , Paul Cairns , John Wright and Joy Adamson BMC Medical Informatics and Decision Making. To see the press release about this paper please follow this link: https://www.york.ac.uk/news-and-events/news/2017/research/digitising-nhs-records/
Thirteen occupational therapists attended the OTIS training day at the University of York on the 9th and 10th of January. The training was facilitated by Shelley Crossland and Professor Avril Drummond. The training was well received by all who attended.
The main paper for the REFORM trial has been accepted by PLOS one.
The RESPECT trial is now open for recruitment!
Hughes-Morley, A., Hann, M., Fraser, C., Meade, O., Lovell, K., Young, B., Roberts, C., Cree, L., More, D., O'Leary, N. and Callaghan, P., 2016. The impact of advertising patient and public involvement on trial recruitment: embedded cluster randomised recruitment trial. Trials,17:586 http://rdcu.be/nE5e