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500th Participant Randomised for UK FROST - 20th December 2017

The UK FROST trial team are delighted to complete recruitment on time and thank our collaborators at participating hospitals for their enthusiasm and commitment to the study. UK FROST is a multi-centre randomised controlled trial comparing early structured physiotherapy with surgical interventions for patients referred to secondary care with a frozen shoulder. The study will be complete in June 2019.


Study Suggests Screening Could Prevent a Quarter of Hip Fractures - December 2017

Community screening for osteoporosis could prevent more than a quarter of hip fractures in older women, new research involving an academic from the University of York suggests. 


Current developments in cluster randomised trials and stepped wedge designs 

Professor Catherine Hewitt and Dr Mona Kanaan attended a meeting on  Current developments in cluster randomised trials and stepped wedge designs at Queen Mary University of London. 


Tailoring evidence-based psychological therapY for People with common mental disorder including Psychotic EXperiences study (TYPPEX)

Dr Mona Kanaan is a co-applicant on a grant which has recently secured funding from the NIHR Programme Grants for Applied Research (PGfAR) Programme. The study will look at Tailoring evidence-based psychological therapY for People with common mental disorder including Psychotic EXperiences study (TYPPEX).  


Secondhand Smoke of Primary School Children in the Capital of Bangladesh, Dhaka

Dr Mona Kanaan was involved in a study that looked at secondhand smoke of primary school children in the capital of Bangladesh, Dhaka. The study found that 95%  of the children surveyed had recently been exposed to secondhand smoke. The results of the study were published in Nicotine & Tobacco Research


HTA Report - December 2017

The HTA report has now been published for Preventing blood-borne virus infection in people who inject drugs in the UK: systematic review, stakeholder interviews, psychosocial intervention development and feasibility randomised controlled trial


Police Knowledge Fund Showcase - 27 November 2017

Dr Arabella Scantlebury presented with Inspector Bill Scott and Dr Nicola Moran at the Police Knowledge Fund Showcase conference in Coventry on: 'Co-producing a bespoke mental health training package for police officers: lessons learnt from the Connect trial.'


Economic Evaluation Alonside Surgical Trials - 21 November 2017

Belen Corbacho attended the 'Economic evaluation alongside surgical trials' meeting on Tuesday 21st November 2017 at St James Priory in Bristol. The objective of the meeting was to support further development of collaborative research and to have an open discussion about the practical and methodological issues that make the design, conduct and analysis of economic evaluation alongside surgical trials unique. 


Grant Secured - November 2017

Professor David Torgerson, Dr Adwoa Parker and Dr Stephen Brealey have recently successfully secured a grant titled: "Developing a training intervention for staff to improve participant recruitment into randomised controlled trials". This is a Centre for Future Health Pump Priming Award from the University of York, via the Wellcome Trust, which has awarded £32,285.35 to develop and pilot test a training course for staff recruiting participants into RCTs. The findings will inform an application for a post-doctoral fellowship for Adwoa Parker.


PROFHER Trial Findings Impact on Surgeons' Clinical Practice - October 2017

The PROFHER trial team published a paper in the October 2017 edition of Bone & Joint Research - see http://bjr.boneandjoint.org.uk/content/6/10/590

PROFHER findings have had an impact on surgeons’ clinical practice, both through reducing the number of operations for patients with a fracture of the upper arm, and through underpinning existing non-operative practice. Dr Stephen Brealey, corresponding author, also featured in this month's edition of the journal.


Published Paper - October 2017

Thirimon Moe Byrne has had a paper published on the NIHR journals library website, entitled 'Certolizumab pegol and secukinumab for treating active psoriatic arthritis following inadequate response to disease-modifying antirheumatic drugs: a systematic review and economic evaluation'. You can read it here.


Regional Surgical Trial Event, Leeds - 6 October 2017

Dr Catriona McDaid and Professor David Torgerson attended and presented at 'Surgical Clinical Trials: From idea to delivery' on Friday 6 October 2017.


Connect Trial - 22 September 2017

The connect trial has had an article published in The Conversation discussing policing and mental health, entitled 'British police dealing with mental health is a sticking plaster solution that doesn't get to the heart of the problem'.


The XXXVII Jornadas de Economica de la Salud - 6-9 September 2017

Belen Corbacho attended the AES (the Spanish Health Economics association) Conference in Barcelona on 6 -9 September 2017. At this conference she organised a panel session on how routine data could be used to improve health care, providing an overview on the use of HES records to conduct economic evauation alongside clinical trials. She also presented a poster on the implications of regional versus centralised HTA for the assessment of cancer drugs.


The Twelfth Annual RCTs Conference in the Social Sciences - 6-8 September 2017

The twelfth annual RCTs Conference on the 6th, 7th and 8th September was a great success. Held at King's Manor, University of York with the conference dinner at Betty's Tea Rooms, it was a true reflection of 'lovely York' for those attending! The conference included a keynote address from Professor Frances Gardner, University of Oxford, invited speakers, presentations and a half day workshop. Over 50 delegates attended the conference, and it was nice to see familiar faces along with new attendees.


Connect Trial - September 2017

The results of the Connect trial, which evaluated the effectiveness of a mental health training package for frontline police officers have now been published in PLOS ONE

The University of York have issued a press release on the results, and the trial has also been featured as a news item by BBC York and North Yorkshire and in the York Press.


500th Participant Randomised for KReBS - 3 September 2017

The YTU team are currently opening more sites and these will aim to recruit a further 2100 patients over the next 6 months. KReBS is a randomised controlled trial investigating the effect of a two-layer compression bandage system on knee function following total knee replacement.


The Smoking Cessation in Pregnancy Incentives Trial (CPIT III) has started - 1 September 2017

CPIT III is a large multi-centre trial which will determine the effectiveness and cost effectiveness of providing financial incentives, in the form of shopping vouchers, to pregnant smokers to engage with smoking cessation services and to quit smoking during and after pregnancy.

The trial is a collaboration with the University of Glasgow and University of Stirling. Joint CI's are Professor David Tappin and Professor Linda Bauld. The Trial Manager is Lesley Sinclair, University of Stirling. YTU staff involved in the project are Professor David Torgerson, Professor Catherine Hewitt, Dr Jude WatsonAda KedingMatthew Bailey and Helen Tilbrook. Management database development, follow-up phone calls to participants and voucher fulfillment have been outsourced to Echo Managed Services Limited who were involved in the pilot study (CPIT II).


OCTET Trial - July 2017

The results of the OCTET Trial, conducted with support of York Trials Unit, have now been published. This trial was undertaken to assess the effectiveness of self help methods for treatment of Obsessive Compulsive Disorder.

Publication of the clinical effectiveness results are available to read online, along with the full HTA monograph.


YUSU Excellence Award - 16 June 2017

Congratulations to Jennifer McCaffery who recently won the YUSU excellence award for the best Postgraduate who Teaches. This was in connection with Jennifer's previous role in the Psychology Department at the University.


Contribution to the Journal of Trauma and Orthopaedics - June 2017

Belen Corbacho has made a contribution to the June issue of the Journal of Trauma and Orthopaedics with her article 'The use of QALYs in the economic evaluation of orthopaedic treatments'


Heart 2016 Award for the Best Paper

Nicole Valtorta, Dr Mona Kanaan's former PhD student, has won the Best Paper award from the Heart journal. Her paper is available to read by here

Publication ID: Heart. 2016 Jul 1;102(13):1009-16. 


International Clinical Trials Methodology Conference - 8 - 10 May 2017

Professor David Torgerson, Dr Adwoa ParkerIzzy ColemanCaroline FairhurstIllary Sbizzera and Catherine Arundel attended the International Clinical Trials Methodology Conference in Liverpool on 8th to 10th May 2017.

The Trials Unit Team are actively involved in trials methodology research and presented a range of different methodology concepts at the conference. These included:

  • A workshop about embedding recruitment and retention interventions into trials organised by Dr Adwoa Parker and a number of posters including:
  • 'Learning from the Octet Trial - Exploring the acceptability of clinical trials management' presented by Catherine Arundel;
  • 'Learning lessons from trial decliners about improving recruitment: qualitative study' presented by Dr Adwoa Parker;
  • 'Evaluating the effectiveness of remote versus online site initiation visits: an embedded randomised controlled feasibility cluster trial within the SWIFFT Trial' presented by Caroline Fairhurst and Izzy Coleman.

Published Paper - May 2017 

Arabella Scantlebury and Alison Booth have had a paper published in the International Journal of Medical Informatics: Experiences, practices and barriers to accessing health information: a qualitative study. Scantlebury A., Booth A., Hanley B. 2017.


Association of Surgeons of Great Britain and Ireland Conference - 3 May 2017

Catherine Arundel presented the results from the SWHSI Pilot Feasibility Trial at the Association of Sugeons of Great Britain and Ireland Conference. If you would like more information about the results please contact Catherine direct via email


Published paper - April 2017

Alison Booth, along with collaborators, has had a paper published, entitled: 'Social prescribing: less rhetoric and more reality'. The paper discusses the advocations and implementation of social prescribing, and the evidence available to judge either the success or value for money of this.


Published paper - April 2017

The Y-SBNT HTA report has now been published.


Poster presentation - 5-6 April 2017

A poster was presented of the SWHSI results at the Tissue Viability Society meeting in Birmingham. The poster was highly commended by the reviewing panel.


Published paper - April 2017

A new publication has been published for the REFORM study:

Cockayne, SFairhurst, C, Adamson, J, Hewitt, C, Hull, R, Hicks, K, Keenan, A-M, Lamb, SE, Green, L, McIntosh, C, Menz, HB, Redmond, AC, Rodgers, S, Torgerson, DJ, Vernon, W, Watson, J, Knapp, P, Rick, J, Bower, P, Eldridge, S, Madurasinghe, VW & Graffy, J 2017, 'An optimised patient information sheet did not significantly increase recruitment or retention in a falls prevention study: an embedded randomised recruitment trialTrials, vol 18, no. 1, pp. 144. DOI: 10.1186/s13063-017-1797-7


OTIS - 3 April 2017

York Trials Unit are pleased to report that we have randomised 117 participants for the OTIS study. These participants have been recruited from sites in Harrogate, Humber, Sheffield and Grimsby. 


Conference Presentation - 24 March 2017

Sarah Cockayne from York Trials Unit, presented the NIHR PHR funded SSHeW trial - a study evaluating the effectiveness of slip resistant footwear to prevent slips, at the Cheshire and Wirral Partnership Research Conference on the 24th March 2017. 


Published Paper - March 2017

The results from the PROTECT feasibility study have been published in Harm Reduction Journal:

The acceptability and feasibility of a brief psychosocial intervention to reduce blood-borne virus risk behaviours among people who inject drugs: a randomised control feasibility trial of a psychosocial intervention (the PROTECT study) versus treatment as usual.

Gail Gilchris, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, John Strang, Avril Taylor and Judith Watson
Harm Reduction Journal201714:14 DOI: 10.1186/s12954-017-0142-5


Trial Forge Workshop - 23 March 2017

Adwoa Parker and David Torgerson attended a Trial Forge workshop in Aberdeen on 23 March to discuss ways of taking forward more Studies Within A Trial (SWATs). Representation from York Trials Unit (YTU) at this meeting was particularly important because YTU undertakes and publishes the most SWATs of any UK trials unit.


Does slip resistant footwear reduce slips among healthcare workers? (SSHeW)

York Trials Unit are pleased to report that recruitment to the SSHeW Trial has begun. Participants are being recruited from Cheshire and Wirral Partnership NHS Foundation Trust and from Leeds Teaching Hospitals NHS Trust in the pilot phase of this study.


KReBS Trial - 6 March

A Randomised Controlled Trial of the Effect of a Two-layer Compression Bandage System on Knee Function Following Total Knee Arthroplasty (KReBS) is now open to recruitment and has randomised its first participant.


Keynote Seminar - 6 March

Professor David Torgerson presented at the Westminster Higher Education Forum Keynote seminar - Using the UK research base to support evidence-based policymaking entitled 'The case for greater use of Randomised Controlled Trials in policy making and the barriers to their use'


Five year follow-up results of the PROFHER trial confirm main trial findings

The ProFHER trial, managed by the York Trials Unit, compared surgery versus none surgery for treatment of adults with a broken bone of the upper arm. The findings published on 1 March 2017 in The Bone & Joint Journal confirm that the main findings of the study over two years are unchanged at five years which is that surgery is no better than a simple sling for treating this broken bone.


Evaluation of the SEM Scanner 200 for the Detection of Early Pressure Ulcers: A Multi-Site Longitudinal Study

Will Eardley, Consultant Orthopaedic Trauma Surgeon and Research Associate, has recently completed recruitment as United Kingdom Chief Investigator for a multi-site longitudinal clinical study. Recruiting ahead of target the Bruin Biometric Evaluation of the SEM Scanner 200 for the detection of early pressure ulcers completed in January. This study investigates the use of detectors of change in skin condition far in advance of clinical signs in routine practice. Mr Eardley recruited hip fracture patients in Middlesbrough as a key element of the trial due to the inherent morbidity associated with this vulnerable population. 


Society for Evidence Based Policing - 3 March 2017

Arabella Scantlebury gave an oral presentation at the Society for Evidence Based Policing called 'A randomised controlled trial of a bespoke mental health training package for front-line officers'. This is part of the Connect project research streams.


£1.9 million to help children from deprived areas brush up on oral health

The York Trials Unit will work with the Universities of Dundee and Sheffield on a £2million project to investigate ways of improving the oral health of young people living in deprived areas.

The researchers will work with 48 schools and nearly 6000 young people in Scotland, England and Wales on the four-year Brushing Reminder 4 Good Oral Health (BRIGHT) initiative.

BRIGHT, funded by the National Institute for Health Research (NIHR), will investigate whether a classroom-based lesson about dental health followed by a series of text messages could increase how often and how well children aged 11-16 brush their teeth – and ultimately reduce levels of tooth decay.

For further information click here.


Does an evidence briefing service for Clinical Commissioning Groups (CCGs) inform decision making?

The answer lies in the newly published report of a controlled trial of a demand led evidence briefing service for CCGs which has now been published in the Health Services and Delivery Research journal on the NIHR Journals Library website:

Wilson, P. M., Farley, K., Bickerdike, E. C., Booth, A. M., Chambers, D., Lambert, M., Thompson, C., Turner, R. & Watt, I. S. (2017). Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services: a controlled before-and-after study. Health Services and Delivery Research. 5, 5, p. 1-164 164 p.


Published Paper - January 2017

The main results of the REFORM study have now been published in PLoS ONE

Cockayne S, Adamson J, Clarke A, Corbacho B, Fairhurst C, Green L, et al. (2017) Cohort Randomised Controlled Trial of a Multifaceted Podiatry Intervention for the Prevention of Falls in Older People (The REFORM Trial). PLoS ONE 12(1): e0168712. doi:10.1371/ journal.pone.0168712


New Study Aims to Improve Rates of Detection in Prostate Cancer

Dr Rhian Gabe took part in the Prostate MRI study (PROMIS) which provides important evidence with respect to future recommendations for the diagnosis of prostate cancer. The study investigated the use of multi-parametric MRI before biopsy in men referred to hospital urology clinics with elevated levels of prostate-specific antigen (PSA). PSA is a protein produced by the prostate gland and increased levels of PSA are an early indicator of cancer cells being present.  For further information click PROMIS study


Methodology Editor - 17 January 2017

Alison Booth is the new Methodology Editor on the British Journal of Radiology (BJR) Editorial Board; her role is to bring specific expertise in reviewing the methodology aspects of all systematic reviews that are submitted to the journal.


Dragon's Den - 13 January 2017

Professor David Torgerson was a member of a Dragon's Den panel for the British Orthopaedic and Trauma Society meeting.


Published Papers - January 2017

Arabella Scantlebury has had two papers published this month:

Arabella Clarke, Ian Watt, Laura Sheard, John Wright, Joy Adamson; Implementing electronic records in NHS secondary care organizations in England: policy and progress since 1998. British Medical Bulletin 2017 1-12. doi: 10.1093/bmb/ldw055

Exploring the implementation of an electronic record into a maternity unit: a qualitative study using Normalisation Process Theory Arabella Scantlebury , Laura Sheard , Ian Watt , Paul Cairns , John Wright and Joy Adamson BMC Medical Informatics and Decision Making. To see the press release about this paper please follow this link: https://www.york.ac.uk/news-and-events/news/2017/research/digitising-nhs-records/


Occupational Therapists Training Event for OTIS - 9 - 10 January 2017

Thirteen occupational therapists attended the OTIS training day at the University of York on the 9th and 10th of January. The training was facilitated by Shelley Crossland and Professor Avril Drummond. The training was well received by all who attended.


REFORM - 9 January 2017

The main paper for the REFORM trial has been accepted by PLOS one.


RESPECT Trial - 9 January 2017

The RESPECT trial is now open for recruitment!


Published Paper - December 2016

Hughes-Morley, A., Hann, M., Fraser, C., Meade, O., Lovell, K., Young, B., Roberts, C., Cree, L., More, D., O'Leary, N. and Callaghan, P., 2016. The impact of advertising patient and public involvement on trial recruitment: embedded cluster randomised recruitment trial. Trials,17:586 http://rdcu.be/nE5e