Active Projects

Cancer

BioDriveAFS – an RCT investigating the impact of a biomarker driven Antifungal Stewardship strategy on antifungal drug use and health related quality of life for patients with acute leukaemia
PORTRAIT - an RCT investigating whether pain and quality of life are improved with post-operative radiotherapy compared to no radiotherapy and whether radiotherapy reduces the likelihood of further surgery in the future
Yorkshire Lung Screening Trial – Evaluating a community-based screening programme and its overall effect across the population
YorQuit - A 3-arm RCT to test the effectiveness and cost effectiveness of smoking cessation interventions within lung cancer screening programmes in Yorkshire

Cardiovascular

FARSTER-Care - An RCT investigating whether, following cardiac surgery with full median sternotomy, an accelerated cardiac rehabilitation pathway will lead to improved patient outcomes and is cost effective compared to the usual timing of cardiac rehabilitation.
RIVIVAL - Randomised placebo-controlled trial of intravenous iron for improving physical performance and quality of life in patients with chronic limb-threatening ischaemia and anaemia following revascularisation.

Education

Elklan - Communication Friendly Settings is a whole-setting programme that aims to promote the speech, language and communication skills of all children.
EPLAYS-2 - Enhancing Pragmatic Language skills for Young children with Social communication impairment: a cluster randomised controlled trial
FINCH – A feasibility RCT of a Forest school intervention to improve the mental health of KS2
children (aged 7-11).
INTERACT - A cluster RCT of Intensive Interaction to support the communication abilities of children and young people with Profound and Multiple Learning Disabilities (PMLD)
MC II – An RCT of the Maths Champions II online programme supporting nursery practitioners to develop numeracy skills for children aged 3-4 years
Next Gen Menfulness - Codesigning a mental health literacy and psychoeducational workshop with adolescent boys using creative arts methods
TDTS – Thinking, Doing, Talking Science: An effectiveness trial of a professional development programme designed to improve year 5 science outcomes
TEEMUP – A professional development programme to develop early numeracy in Reception and Year 1 pupils: a cluster randomised controlled trial
Year 6 Science – A multi-phase project to develop a Year 6 science attainment assessment for use as an evaluation outcome measure

Global Health

COPE-BP - COmmunity-Pharmacies managing hypertension: intervention development and Evaluation in Bangladesh and Pakistan
DIADEM - Developing and evaluating an adapted behavioural activation intervention for people with depression and diabetes in South Asia
EXTRA-CeCi - Extra Community-based Enhanced Care Intervention: A cluster randomised controlled trial of community-based person-centred enhanced care for people with HIV/AIDS in Ghana.
SCIMITAR-SA - Smoking Cessation For People With Severe Illness In South Asia
The IMPACT Centre - Research centre to improve mental and physical health in Afghanistan and Pakistan
Tobacco-Free Cities - Implementation research to create tobacco free cities in Pakistan, Bangladesh and Vietnam

Mental Health and Addiction

AMICABLE - Addressing Mental health In Custody A Brief Learning Environment
ARMS - Mapping implementation of At-Risk Mental State. This study will investigate how specialist services for people at high risk of developing psychosis are organised and delivered across England.
ARROW: Assessing Residential Rehabilitation fOr Women. A feasibility RCT to access the feasibility of a women only, gender- and trauma-informed residential rehabilitation pathway for drug dependent women leaving prison.
BART II - An RCT to evaluate the effectiveness of Cognitive Behaviour Therapy (CBT) for individuals who meet the criteria for being at risk of developing bipolar disorder.
BASIL – An RCT of the BASIL programme, a psychological intervention, for mitigating depression and loneliness during the Covid-19 pandemic in older people with long-term health conditions
BAY - An RCT investigating behavioural activation for moderately to severely depressed young people in CAMHS settings
CASCADE - Case finding for depression in primary care
ComBAT- A randomised controlled trial to determine the clinical and cost-effectiveness of community-based behavioural activation training in young people (aged 12 to 18 years) with mild-to-moderate depression delivered in the NHS, schools, and third sector organisations such as charities.
DIAMONDS - An RCT of the DIAMONDS Programme investigating the clinical and cost-effectiveness of the DIAMONDS intervention (diabetes self-management programme) for people with severe mental illnesses (SMI) and type 2 diabetes.
FINCH – A feasibility RCT of a Forest school intervention to improve the mental health of KS2
children (aged 7-11).
IBPI - An RCT evaluating the clinical and cost-effectiveness of an online integrated bipolar parenting intervention to improve child emotional and behavioural problems.
MODS – A programme aiming to develop and evaluate an intervention to improve physical and psychological functioning in older adults with long-term physical health conditions and low mood or depression
moreRESPECT - An RCT to investigate whether an intervention designed to promote sexual health for people with severe mental illness is clinically and cost effective.
Next Gen Menfulness - Codesigning a mental health literacy and psychoeducational workshop with adolescent boys using creative arts methods
N-READY - Improving Effectiveness Of Nicotine Replacement Therapy
PPB - Partners of Parents with Bipolar
SCEPTRE: A feasibility RCT of the SCEPTRE intervention to support smoking cessation and prevent relapse to tobacco use following a smoke free mental health inpatient stay
YorQuit - A 3-arm RCT to test the effectiveness and cost effectiveness of smoking cessation interventions within lung cancer screening programmes in Yorkshire

Musculoskeletal

HAMLET - A multicentre, two-arm, non-blinded, pragmatic, parallel group, randomised controlled superiority trial assessing the clinical and cost effectiveness of Through Knee Amputation (TKA) compared to Above Knee Amputation (AKA) in patients requiring major lower limb amputations (MMLA), but who are unsuitable for a Below Knee Amputation (BKA).
OPAL2 - A multi-centre RCT comparing the OPAL occupational support programme with usual care on the time to return-to-work in patients undergoing elective hip or knee replacement surgery.
RIVIVAL - Randomised placebo-controlled trial of intravenous iron for improving physical performance and quality of life in patients with chronic limb-threatening ischaemia and anaemia following revascularisation.
SCOOTT - A multi-centre, superiority and non-inferiority three-arm RCT to assess the clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement.
SORE Elbow - A feasibility trial for conducting a RCT evaluating the clinical and cost-effectiveness of surgery versus physiotherapy for adults with Tennis Elbow persisting for more than 6 months.
SPINE - Scoliosis Patient Imaging Needs Evaluation

Oral Health

CALM – An RCT of a guided self-help cognitive behavioural therapy to reduce dental anxiety in children attending primary dental care

Pharmaceutical

BioDriveAFS – an RCT investigating the impact of a biomarker driven Antifungal Stewardship strategy on antifungal drug use and health related quality of life for patients with acute leukaemia
EXTEND – An RCT determining the effectiveness of longer antibiotic courses in improving intra-abdominal infection patient outcomes
FIRST – A multicentre, double-blind, randomised, placebo-controlled, superiority trial with an internal pilot and cost effectiveness analysis to determine if early treatment with rituximab in children and adults with moderate/severe lupus is superior to usual care.
PERISCOPE - What are the benefits and harms of continuation versus stoppage of biologics in patients with inflammatory arthritis (IA) undergoing orthopaedic surgery?
RIVIVAL - Randomised placebo-controlled trial of intravenous iron for improving physical performance and quality of life in patients with chronic limb-threatening ischaemia and anaemia following revascularisation.
TIDE – An RCT investigating whether there are effective alternatives to nasal mupirocin for early decolonisation of MRSA amongst adult hospital in-patients

Primary care and community

BATH-OUT-2 – An RCT of the effectiveness and cost effectiveness of bathing adaptations in the homes of older adults on health, safety and quality of life
CALM – An RCT of guided self-help cognitive behavioural therapy to reduce dental anxiety in children attending primary dental care
CASCADE - Case finding for depression in primary care
IMAB-Qi - Five Year (2024-2029) England-wide research programme that aims to help patients to take their medication as prescribed.
INGEST: dIscontinuing or continuiNG thickEned fluidS Trial - A multi-centre Randomised Controlled Trial to determine the clinical and cost effectiveness of discontinuing thickened fluids compared to continuing thickened fluids in adults with slowly progressing oropharyngeal dysphagia.

Public health and prevention

CHARMER - An England-wide research project that aims to help address overprescribing in the NHS
ELEVATE - A mixed methods study identifying innovative models of emergency care in rural and coastal areas of England
EXTEND – An RCT determining the effectiveness of longer antibiotic courses in improving intra-abdominal infection patient outcomes
FINCH – A feasibility RCT of a Forest school intervention to improve the mental health of KS2
children (aged 7-11).
N-READY - Improving Effectiveness Of Nicotine Replacement Therapy
OPAL2 - A multi-centre RCT comparing the OPAL occupational support programme with usual care on the time to return-to-work in patients undergoing elective hip or knee replacement surgery.
Response Study: a multidisciplinary NIHR-funded project investigating the implementation of the Patient Safety Incident Response Framework in NHS.
SAM-I - Safe Administration of Medicines – Intervention (SAM-I) – The development and evaluation of an intervention to de-implement unnecessary double-checking of medicines in hospital.
SAVINGS - an RCT assessing the effects of very brief smoking cessation advice delivered by financial guidance services to adults receiving support for financial difficulties
STRIVE - STRategies for the Identification, enrolment, attendance and retention of families into parenting interVentions in Early life
TIDE – An RCT investigating alternatives to nasal mupirocin for early nasal decolonisation of MRSA amongst adult hospital in-patients

Respiratory

SAVINGS - an RCT assessing the effects of very brief smoking cessation advice delivered by financial guidance services to adults receiving support for financial difficulties.
UPTURN - Co-design And Evaluation Of An Intervention To Increase UPTake Of PUlmonary RehabilitatioN For People Living With Chronic Obstructive Pulmonary Disease
YorQuit - A 3-arm RCT to test the effectiveness and cost effectiveness of smoking cessation interventions within lung cancer screening programmes in Yorkshire

Screening

CASCADE - Case finding for depression in primary care
Yorkshire Lung Screening Trial – Evaluating a community-based screening programme and its overall effect across the population
YorQuit - A 3-arm RCT to test the effectiveness and cost effectiveness of smoking cessation interventions within lung cancer screening programmes in Yorkshire

Surgery and devices

CAREFUL – A feasibility study investigating the impact of continuous arterial monitoring in elderly patients living with frailty for hip fracture surgery to prevent low blood pressure.
DIDACT - Multi-centre randomised controlled trial to assess the effectiveness and cost-effectiveness of surgery compared with sling immobilisation in the management of adults with radiological diagnosis of a displaced fracture of the distal clavicle that does not involve the acromioclavicular joint.
FARSTER-Care - An RCT investigating whether, following cardiac surgery with full median sternotomy, an accelerated cardiac rehabilitation pathway will lead to improved patient outcomes and is cost effective compared to the usual timing of cardiac rehabilitation.
HAMLET - A multicentre, two-arm, non-blinded, pragmatic, parallel group, randomised controlled superiority trial assessing the clinical and cost effectiveness of Through Knee Amputation (TKA) compared to Above Knee Amputation (AKA) in patients requiring major lower limb amputations (MMLA), but who are unsuitable for a Below Knee Amputation (BKA).
MEASURE - A national, mixed-methods study to evaluate the impact of High-volume low-complexity surgical hubs in England.
MoTIF - A study which evaluates how NHS Targeted Investment Fund projects outside surgical hubs were implemented and their impact on patient care, staff experience, and service delivery across England.
PERISCOPE - What are the benefits and harms of continuation versus stoppage of biologics in patients with inflammatory arthritis (IA) undergoing orthopaedic surgery?
PROLLIT – A study to develop a Patient Reported Outcome Measure (PROM) for lower limb reconstruction
RAPSODI - An RCT assessing whether reverse total shoulder replacement is superior to an anatomical total shoulder replacement for the treatment of painful osteoarthritis of the shoulder joint in patients over 60 years old.
RESTART PD - A multicentre, two-arm, non-blinded, pragmatic, parallel group, randomised controlled superiority trial with the aim of assessing the clinical and cost effectiveness of Reality DTx®compared with traditional physiotherapy for patients with Parkinson’s Disease.
SCOOTT - A multi-centre, superiority and non-inferiority three-arm RCT to assess the clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement.
SInUS- A randomised controlled trial to find out if the Segmental intra-ureteric stent (SIS) is better than the Polymeric short-term stent (PSS). We will be looking at whether SIS reduces symptoms, the number of surgeries needed, NHS costs, and if it can improve patients’ quality of life.
SORE Elbow - A feasibility trial for conducting a RCT evaluating the clinical and cost-effectiveness of surgery versus physiotherapy for adults with Tennis Elbow persisting for more than 6 months.

Wounds

REDUCE – A pilot study of the effectiveness of an intervention to prevent diabetic foot ulcer recurrence
SHED SSc – Sharp debridement of digital ulcers in Systemic Sclerosis: a multi-centre randomised controlled feasibility study