Research Fellow in Intelligent and Adaptive Systems
Research area: Intelligent Systems Group
Areas of expertise: Computational Immunology, Computational and Mathematical Modelling, Argumentation, Sensitivity Analysis and Statistical Methods
I am a Research Fellow in Intelligent and Adaptive Systems at the University of York's Department of Electronics and York Computational Immunology Lab, alongside assisting Professor Jon Timmis' ongoing research activities during his term as Pro-Vice-Chancellor.
I am an interdisciplinary researcher who examines the engineering processes through which models and simulations are developed that help us understand real systems, historically biological and immunological systems, to increase confidence in using models to guide experiments and to reduce animal experimentation. These approaches encapsulate the complete process of model and simulation development, from conception through design, implementation, analysis, and relating the results to the real-world.
The vast majority of my research is conducted in close collaboration with York’s Centre for Immunology and Infection. Since October 2015 I also work closely with the York Robotics Lab, who use simulations to develop biologically-inspired algorithms for use in robotics. I have also begun working with the researchers in York’s Centre for Health Economics, to examine the use of our approaches in models of cost-effectiveness of healthcare provision.
I studied Computer Science at Royal Holloway, University of London before completing a Masters of Research in Computational Biology at York. I stayed at York to complete a PhD, jointly funded by the Centre for Immunology and Infection and Department of Computer Science, then spent just over a year as a Research Fellow at the Centre for Systems Biology at the University of Birmingham, funded by the National Centre for the Replacement, Refinement, and Reduction of Animals in Rsearch (NC3R's). I returned to York in March 2013, to develop integrated approaches to modelling immunological systems. Since October 2015 I have been in my current role at the Department of Electronic Engineering, conducting my own research while assisting the management of the York Computational Immunology Lab and York Robotics Laboratory, working with external academics and industrial partners, and generating new grant applications and collaborations.
I also spent a short spell at Phil Bourne's lab at the University of California San Diego in 2008, and a further spell in 2012. My work there focused on the development of software tools that assist research conducted by structural biologists.
I maintain the SPARTAN Toolkit, developed here in York to help understand the relationship between a simulation and the biological system that it has been built to represent. I also continue to work with Phil Bourne's lab on dConsensus, a tool I developed while at UCSD, which is in the process of being migrated to services at the NIH.