Kieran initially joined the group in 2009 and completed a PhD in Biology in 2012, supervised by Prof Jon Timmis and Dr. Mark Coles. His PhD focused on the development of lympoid organs that trigger adaptive immune responses. He oversaw the development of the spartan software tool developed by the lab, a package of statistical techniques specifically designed to help establish the relationship between a simulation and the real world system and to provide novel biological insight. Kieran left in January 2013 to work at the University of Birmingham as a NC3Rs Fellow, but returned to YCIL in March 2014, funded by the C2D2 Consolidator grant. Since October 2015 he has worked within the Department of Electronics as a Research Associate in Intelligent and Adaptive Systems, focusing on the engineering techniques used to develop simulations of biological systems.
|James A. Butler||
James joined the group in 2012, as a postgraduate researcher with the White Rose Doctoral Training Centrefor Tissue Engineering and Regenerative Medicine, a program founded by the Universities of York, Leeds and Sheffield to develop effective clinical therapies for the treatment of human diseases and disabilities. His PhD is supervised by Dr. Mark Coles and Prof. Jon Timmis, focused on the development of lymphoid tissue in normal and autoimmune scenarios.
Jason is a PhD student in the Coles and Timmis labs, and focuses on characterising cellular architectures using a combination of experimental and theoretical approaches. The focus of his PhD project is to explore how stromal remodelling can affect immune function in lymph nodes
Simon is a PhD student with a background in mathematics and computer science. He is working on computational models of the immune system, particularly looking at therapeutic interventions for type 1 diabetes. He is working with Prof. Jon Timmis (Electronics) and Dr. Mark Coles (CII).
|John Hamp||John joined the university in 2014 as an MRC iCASE PhD student in the Centre for Immunology and Infection, supervised by Jon Timmis and Paul Kaye, with Pharmidex as the industrial partner. His project aims to build upon an existing model of Leishmaniasis and incorporate Pharmacokinetic and Pharmacodynamic modelling elements to examine therapeutic regimes for this disease.|
Paul joined the university & the Centre for Immunology & Infection (CII) in 2015. His research focuses on modelling & simulation of immune system activation by vaccine adjuvants, in order to better understand their mechanism of action in mice and human systems, as-well as understanding differences between the species. His project aims to develop a simulation of adjuvant-driven immune responses in a lymph node, and to utilise the model to better understand cellular dynamics, and also utilise computational analyses to determine optimal conditions and dosing strategies for the development of effective immune responses. Paul is funded by BBSRC through the iCASE programme.