Research at YCIL has been funded by the following bodies and awards:
With the award of this grant, YCIL will develop a collaborative research environment, develop and support open tools for modelling, and demonstrate leadership through holding an international workshop in 2014 on systems immunology. We will apply computational approaches to understand mechanisms driving immune tissue function, homeostasis and remodelling and test the hypotheses emerging from the models in vivo. The award of this grant enabled YCIL to hire Dr Kieran Alden.
YCIL Members Paul Kaye, Jon Timmis, Dimitris Lagos, and Mark Coles, part of a consortium of researchers from a number of institutions, have been awarded funding after winning an NC3R's Crack-It Challenge. The consortium were successful in the Virtual Infectious Disease Challenge competition, aiming to develop a reliable computer-based model of the dynamics of infection and treatment response within an individual host. This work follows the successful bid for £100,000 to carry out early proof-of-concept studies, work conducted in YCIL by Simon Hickinbotham, Jon Timmis, and Paul Kaye. This proof-of-concept was presented to NC3R's, successfully competing against others to win £1 million in the final round of the challenge.
The computer model that the team will now develop further is intended to help predict the efficacy of drugs, vaccines and other treatments for leishmaniasis. Use of this technology is expected to significantly reduce the number of rodents needed in the pre-clinical stages of drug and vaccine development, given that a typical rodent efficacy study for new antibiotics or vaccines might involve up to 100 animals per candidate drug.
YCIL PhD students are funded by studentships from funding bodies BBSRC, EPSRC, and the Wellcome-Trust (through the CIDCATS programme at the University of York), as well as CASE studentships funded by the pharmaceutical company GSK.