We are involved in two main areas of research which are often interlinked. The first is the synthesis of natural product and related compounds of biological interest. In order to carry out efficient target molecule synthesis, it is often necessary to develop new synthetic methodology. This leads on to the second main research area, the development of new synthetic transformations, particularly those using organometallic and organosulfur reagents, and new catalytic processes. We are also interested in the design of new telescoped and cascade organic transformations (including tandem oxidation processes, TOP) with environmental benefits.
A number of natural product targets have been targeted using the above chemistry including the potent anticancer and antibiotic agents ajudazol A colletofragarone A, daphnezomine N, dictyosphaeric acid, grandisine B, integrastatin A, janoxepine, oxazolomycin A and 'upenamide (see below).
In terms of methodology the following areas are of current interest:
3D view of (-)-grandisine B: A natural product synthesised in our group