Dr Alexandra Males

Responsibilities

Responsibilities

My responsibilities at York are:

• Senior demonstrator in undergraduate practicals,
• Practical course co-coordinator for year 1 laboratory course,
• Deliver tutorials, workshops and lectures to undergraduate students.

Selected publications

Selected publications

• Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications
  González-Cuesta et al, J. Am. Chem. Soc, 2022, 144 (2), 832-844
• Development of non-hydrolysable oligosaccharide activity-based inactivators for endoglycanases: A case study on α-1,6 mannanases
  Schröder et al, Chem. Eur. J, 2021, 27, 9519-9523
• Mannosidase mechanism: at the intersection of conformation and catalysis 
  Rovira et al, Curr Opin Struct Biol, 2019, 62, 79-92
• Distortion of mannoimidazole supports a B_2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens
  Males et al, Org. Biomol. Chem, 2019, 17 (34), 7863-7869
• A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites
  Sernee et al, Cell Host Microbe, 2019, 26 (3), 385-399.e.9
• Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes
  King et al, Curr Opin Chem Biol, 2019, 53, 131-144
  
• Structural studies of a surface-entropy reduction mutant of O-GlcNAcase
  Males et al, Acta Crystallogr D Struct Biol, 2019, 75 (Pt 1), 70-78
• Conformational Analysis of the Mannosidase Inhibitor Kifunensine: A Quantum Mechanical and Structural Approach
  Males et al, ChemBioChem, 2017, 18 (15), 1496-1501
• Conformational Behaviour of Azasugars Based on Mannuronic Acid
  van Rijssel et al, ChemBioChem, 2017, 18 (13), 1297-1304
• Computational Design of Experiment Unveils the Conformational Reaction Coordinate of GH125 α-Mannosidases
  Alonso-Gil et al, JACS, 2017, 139 (3), 1085-1088
• Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications
  González-Cuesta et al, J. Am. Chem. Soc, 2022, 144 (2), 832-844
• Development of non-hydrolysable oligosaccharide activity-based inactivators for endoglycanases: A case study on α-1,6 mannanases
  Schröder et al, Chem. Eur. J, 2021, 27, 9519-9523