Dr Saioa Urresti

Telephone: (+44) (0)1904 32 8278
Email: saioa.urresti@york.ac.uk

Postdoctoral Research Associate

Research Interests

Saioa Urresti is a PDRA working in the York Structural Biology Laboratory (YSBL) under the supervision of Professors Gideon J. Davies, FRS and Paul H. Walton. She works on metal-dependent carbohydrate modifying enzymes. Her main project is the discovery and analysis of novel lytic polysaccharide monooxygenases (LPMOs), which are copper-dependent enzymes from the Auxiliary Activities AA9, AA10, AA11, AA13, AA14 and AA15 families (www.cazy.org). These enzymes are able to cleave polysaccharides, such as cellulose or chitin, turning them into more accessible substrates for other glycoside hydrolases. This potentially increases the suitability of waste carbohydrates as substrates for biofuel production (second generation of biofuels).

Publications

2018. Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum.
Urresti S, Cartmell A., Liu F., Walton PH and Davies GJ. Acta Cryst. F Struc. Biol. Commun., 74 (8): 496-505.

2017. Structural snapshots and loop dynamics along the catalytic cycle of glycosyltransferase GpgS.
Albesa-Jove D, Romero-Garcia J, Sancho-Vaello E, Contreras FX, Rodrigo-Unzueta A, Comino N, Carreras-Gonzalez A, Arrasate P, Urresti S, Biarnes X, Planas A and Guerin ME. Structure, 25 (7): 1034-1044.

2015.Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H. Nat. Commun. 6: 10197.

2015. The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053.
Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, Riccardi G, Svergun DI, Glockshuber R, Guerin ME. J. Biol. Chem. 290 (52):31077-31089

2015. A native ternary complex trapped in a crystal reveals the catalytic mechanism of a retaining glycosyltransferase.
Albesa-Jové D, Mendoza F, Rodrigo-Unzueta A, Gomollón-Bel F, Cifuente JO, Urresti S, Comino N, Gómez H, Romero-García J, Lluch JM, Sancho-Vaello E, Biarnés X, Planas A, Merino P, Masgrau L, Guerin ME. Angew. Chem. Int. Edit., 54 (34): 9898-9902.

2015. Secondary structure reshuffling modulates the enzymatic activity of a GT-B glycosyltransferase at the membrane interface.
Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM. Nature Chem. Biol. 11 (1): 16-18.

2014. Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Albesa-Jové D, Chiarelli LR, Makarov V, Pasca MR, Urresti S, Mori G, Salina E, Vocat A, Comino N, Mohorko E, Ryabova S, Pfieiffer B, Lopes Ribeiro AL, Rodrigo-Unzueta A, Tersa M, Zanoni G, Buroni S, Altmann KH, Hartkoorn RC, Glockshuber R, Cole ST, Riccardi G, Guerin ME. ACS Chem. Biol., 9 (7): 1567-1675.

2013. Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria.
Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME. J. Biol. Chem., 288 (41): 29797-29808.

2012. Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME. J. Biol. Chem., 287 (29): 24649-24661.

 

Dr Saioa Urresti