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Dr Qingyun Tang

Tel: +44 (0)1904 32 8687
Email: qingyun.tang@york.ac.uk

Postdoctoral Research Associate

Qingyun is a PDRA working in the York Structural Biology Laboratory (YSBL) with Prof. Gideon Grogan and Prof. Ian Fairlamb in the group of organic chemistry. She completed her PhD in Biochemistry at the University of Greifswald, Germany in 2021, where she investigated catalytic promiscuity of SAM-dependent methyltransferases under the supervision of Prof. Uwe Bornscheuer. Her current research focuses on the discovery of functional amide bond synthetases (ABSs) for the synthesis of valuable pharmaceutical amides. Approaches including protein engineering of existing ABSs, high-throughput screening of active ABSs, protein X-ray crystallography and cofactor regeneration will be employed.

Selected Publications

  • From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases. Q. Tang et al., ChemBioChem 2021, in press. DOI: 10.1002/cbic.202100153.
  • Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs.
  • Q. Tang et al., Angew. Chem., Int. Ed. 2021, 60, 1524-1527. DOI: 10.1002/anie.202013871.
  • Influence of Substrate Binding Residues on the Substrate Scope and Regioselectivity of a Plant O‐Methyltransferase against Flavonoids.
  • Q. Tang et al., ChemCatChem 2020, 12, 3721–3727. DOI: 10.1002/cctc.202000471.
  • Specific Residues Expand the Substrate Scope and Enhance the Regioselectivity of a Plant O‐Methyltransferase.
  • Q. Tang et al., ChemCatChem 2019, 11, 3227-3233. DOI: 10.1002/cctc.201900606.
  • Site‐directed mutagenesis studies of hydrophobic residues in the lid region of T1 lipase.
  • Q. Tang et al., Eur. J. Lipid Sci. Technol. 2017, 119. DOI: 10.1002/ejlt.201600107.
  • Lipase-Driven Epoxidation Is A Two-Stage Synergistic Process.
  • Q. Tang et al., Chemistryselect 2016, 1, 836-839. DOI: 10.1002/slct.201600254.