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Dr Nicholas McGregor

Tel: (+44) (0)1904 32 8278
Email: nicholas.mcgregor@york.ac.uk

Postdoctoral Research Associate

Nicholas McGregor is a post-doctoral research associate working with Professor Gideon Davies, FMedSci, FRS. He is developing and demonstrating methods using selective covalent labels to discover and characterise glycoside hydrolases. Following the completion of a BSc in Chemical Biology at McMaster University in 2012, he obtained a PhD from the University of British Columbia in 2018 and joined the York Structural Biology Laboratory that year. He has experience in enzyme active site labelling, enzyme kinetics, peptide/protein/carbohydrate mass spectrometry, and protein X-ray crystallography. 

Selected Publications

  • Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases
    McGregor, N. G. S. et al, J. Am. Chem. Soc., 2020, 142, 4648–4662
  • Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
    De Boer, C. et al, RSC Chem Biol, 2020, in press
  • Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes
    Schröder, S. P. et al, ACS Cent. Sci., 2019, 5, 1067–1078
  • Structural Dynamics and Catalytic Properties of a Multi-Modular Xanthanase 
    Moroz et al, ACS Catalysis, 2018, 8 (7), 6021–6034 
  • Structure-Function Analysis of a Mixed-linkage β-Glucanase/Xyloglucanase from the Key Ruminal Bacteroidetes Prevotella bryantii B14 
    McGregor et al, J Biol Chem, 2018, 291 (3) 1175-1197 
  • Molecular Characterization of N-glycan degradation and transport in Streptococcus pneumoniae and its contribution to virulence 
    Robb et al, PLOS Pathogens, 2017, 13 (1) e1006090 
  • Crystallographic Insight into the Evolutionary Origins of Xyloglucan Endo-Transglycosylases and Endo-Hydrolases 
    McGregor et al, Plant J, 2017, 89 (4) 651-670

York Research Database link

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ORCID logo‌https://orcid.org/0000-0003-1075-7368