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Dr Mia Shandell

Tel: (+44) (0)1904 32 8276
Email: mia.shandell@york.ac.uk

Postdoctoral Research Associate

Mia is a Postdoctoral Research Associate working with Dr Lianne Willems at the York Structural Biology Laboratory. Previously, Mia investigated how the ionic tumour microenvironment impacts checkpoint protein expression in cancer cells with Dr Dimitris Lagos and Dr William Brackenbury at the University of York. She completed her PhD in Pharmacology from Columbia University in 2017 where she developed new fluorescent labeling and live cell imaging methods for studying human cardiac voltage-gated sodium channels.

 

Research Interests

Her current project focuses on investigation of mammalian phosphoribitol transferases using novel labelling and activity probes. Genetic mutation of these enzymes result in aberrant glycosylation of their targets, resulting in a variety of congenital muscular dystrophies. This work will further our understanding of this glycosylation pathway, providing much needed insight on the underlying mechanisms of clinically relevant mutations.

Selected Publications

  • Detection of Nav1.5 Conformational Change in Mammalian Cells Using the Noncanonical Amino Acid ANAP
    Shandell, M. A., et al., Biophysical Journal, 2019, DOI: 10.1016/j.bpj.2019.08.028
  • In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes.Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
    Iverson, N. M., et al., Nature Nanotechnology, 2013, DOI: 10.1038/nnano.2013.222
  • Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes
    Zhang, J., et al., Nature Nanotechnology, 2013, DOI: 10.1038/nnano.2013.236 
  • Controllable Synthesis of Single-Walled Carbon Nanotube Framework Membranes and Capsules
    Song, C., et al., Nano Letters, 2009, DOI: 10.1021/nl902518b