Dr Liang Wu

Tel: (+44) (0)1904 32 8278
Email: liang.wu@york.ac.uk

Postdoctoral Research Associate

Research interests

Liang Wu is a PDRA in the group of Professor Gideon Davies, FMedSci, FRS. His main research focus is the structural and functional characterization of human carbohydrate processing enzymes associated with lysosomal storage diseases. He also maintains an interest in higher eukaryotic protein production techniques, specializing in the baculovirus system.

Recent publications

  • Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae
    Wu et al., Acta Crystallography, 2018, F74, 512-523
  • Gluco-1H-imidazole; a new class of azole-type β-glucosidase inhibitor
    Schröder et al., J Am Chem Soc, 2018, 140, 5045-5048
  • Activity based probes for functional interrogation of retaining β-glucuronidases
    Wu et al., Nature Chemical Biology, 2017, 13, 867–873
  • A fluorescence polarization activity-based protein profiling assay in the discovery of potent, selective inhibitors for human non-lysosomal glucosylceramidase
    Lahav et al., J Am Chem Soc, 2017, 139, 14192-14197
  • 1,6-Cyclophellitol cyclosulfates: A new class of irreversible glycosidase inhibitor
    Artola et al., ACS Central Science, 2017, 3, 784-793
  • Detection of active mammalian GH31 α‑Glucosidases in health and disease using in-class, broad-spectrum activity-based probes
    Jiang et al., ACS Central Science, 2016, 2, 351-358
  • Bacterial beta-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (GBA2)
    Charoenwattanasatien et al., ACS Chemical Biology, 2016, 11, 1891-1900
  • Structural characterization of human heparanase reveals insights into substrate recognition
    Wu et al., Nature Struct Mol Biol, 2015, 22, 1016-1022

 

Dr Liang Wu

York Research Database link

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ORCID logohttps://orcid.org/0000-0003-0294-7065