Research within this theme focuses on the functions and applications of metal ions in biological systems. Main areas of interest include: metalloprotein structure, function and mode-of-action, especially of biomass-degrading enzymes, such as lytic polysaccharide monooxygenases and hydrogenases, siderophore-binding proteins and artificial metalloenzymes. New antimicrobials are a target of research into siderophore-conjugates, CO-releasing molecules and redox-active bacterial enzymes. A wide range of techniques are used to interrogate proteins, most notably structural methods, magnetic spectroscopy, electrochemistry and small molecule models. On a whole organism scale, diagnostically-resolved magnetic resonance imaging is being utilised to monitor in situ drug metabolism via hyperpolarisation methods that utilise molecular catalysts. These techniques are augmented with DFT computational theory, genomic discovery, chemical and molecular biology. Further information about this theme can be found on the Inorganic chemistry page.