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York Chemists awarded £628k by EPSRC

Posted on 16 May 2014

Dr Anne-Kathrin Duhme-Klair and Prof Keith Wilson have been awarded £628k by the EPSRC for a project entitled “Siderophores as anchors in artificial metalloenzymes“

The project involves the development of artificial metalloenzymes that consist of a synthetic catalytic centre that is linked via a siderophore-based anchor group to a bacterial siderophore binding protein that acts as a scaffold.  This design allows the combination of the chemical reactivity of synthetic catalysts with the selectivity and biocompatibility of proteins.

Structure of a siderophore binding protein with bound anchor group, highlighting the pocket available for the accommodation of a synthetic catalyst (protein: electrostatic surface representation; anchor group: Fe grey, C green, O red, N blue).

Structure of a siderophore binding protein with bound anchor group, highlighting the pocket available for the accommodation of a synthetic catalyst (protein: electrostatic surface representation; anchor group: Fe grey, C green, O red, N blue).