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Exploiting large-scale preference data to make health economic studies more policy-relevant

Thursday 11 May 2017, 2.00PM to 3.15pm

Speaker(s): Richard Grieve PhD, Professor of Health Economics Methodology, LSHTM

Abstract: Randomised controlled trials (RCTs) tend to include atypical patients and centres, and the accompanying cost-effectiveness analyses (CEA) may be subject to sample selection bias. Approaches have been developed that use observational data to reweight trial-based estimates, but assume all relevant covariates have been observed. However, differences between the RCT and the target population of interest tend to remain unobserved. In particular, trial participants may have unusual preferences, partly because of selection into the trial, but also due to their experiences during the RCT.  

I consider the problem that trial populations may have atypical preferences, with the example of the Health Economics Modelling Of alternative blood donation strategies (HEMO study). The study undertook a stated preference (SP) survey to elicit the preferences of blood donors for alternative strategies for maintaining the blood supply. The study contrasts the preferences of trial participants (n=4,000), with those from a sample (n=25,000) drawn from the target population of interest. I report the differences in preferences between the trial and target population settings, raise hypotheses for why these differences may exist, and consider the impact on the cost-effectiveness results.

The talk concludes by considering the general implications of these differences in preferences between the trial and target population settings, and the implications for any attempts to personalise health services according to individual preferences.

Location: ARRC Auditorium A/RC/014

Who to contact

For more information on these seminars, contact:

Adrian Villasenor
Adrian Villasenor-Lopez
Dacheng Huo
Dacheng Huo

If you are not a member of University of York staff and are interested in attending the seminar, please contact Adrian Villasenor-Lopez or Dacheng Huo so that we can ensure we have sufficient space

CHE Seminar Programme

  • Monday 21 January
    Professor Rachel Baker, Yunus Centre for Social Business and Health
  • Thursday 7 February
    Professor Philip Clarke, The Universities of Melbourne and Oxford
  • Thursday 7 March
    Professor Sonia Bhalhotra, University of Essex 
  • Thursday 4 April 
    Eugenio Zucchelli, Lancaster University
  • Monday 13 May
    Davide Rasella, Fiocruz Brazil
  • Thursday 4 July
    Stephanie von Hinke Kessler Scholder, Bristol University
  • Thursday 5 September
    Jose-Luis Fernandez, LSE 
  • Thursday 3 October
    Soren Rud Kristensen, Imperial
  • Thursday 7 November
    Linda Davies, Manchester University
  • Wednesday 5 December
    Mandy Ryan, HERU, University of Aberdeen