The Cancer Research Unit, Department of Biology,
University of York,
York. YO10 5DD. UK.

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The Cancer Research Unit

Publications from CRU


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Peitzsch C, Cojoc M, Hein L, Kurth I, M?bert K, Trautmann F, Klink B, Schrock E, Wirth MP, Krause M, Stakhovsky EA, Telegeev GD, Novotny V, Toma MI, Muders M, Baretton GB, Frame FM, Maitland NJ, Baumann M, Dubrovska A.  An epigenetic reprogramming strategy to re-sensitize radioresistant prostate cancer cells..  Cancer Res. 2016 Mar 16. pii: canres.2116.2015. [Epub ahead of print]

Miftakhova R, Hedblom A, Semenas J, Robinson BD, Simoulis A, Malm J, Rizvanov A, David Heery D, Mongan NP, Maitland NJ, Allegrucci C, Persson JL.  Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. Cancer Res. 2016 Feb 26. pii: canres.2340.2015. [Epub ahead of print]

Packer JR, Maitland NJ. The molecular and cellular origin of human prostate cancer. Biochim Biophys Acta. 2016 Feb 26. pii: S0167-4889(16)30041-6. doi: 10.1016/j.bbamcr.2016.02.016. [Epub ahead of print] Review.

Frame FM, Savoie H, Bryden F, Giuntini F, Mann VM, Simms MS, Boyle RW, Maitland NJ. Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis. Cancer Med. 2016 Jan;5(1):61-73. doi: 10.1002/cam4.553. Epub 2015 Nov 21.

Hirst AM, Frame FM, Arya M, Maitland NJ, O'Connell D. Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future. Tumour Biol. 2016 Feb 18.


Rane, J. K., Greener, S., Frame, F. M., Mann, V. M., Simms, M. S., Collins, A. T., Berney, D. M. & Maitland, N. J Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages.  8 Oct 2015 In : European Urology

Rane JK, Scaravilli M, Ylipää A, Pellacani D, Mann VM, Simms MS Nykter M, Collins AT, Visakorpi T, Maitland NJ. MicroRNA Expression Profile of Primary Prostate Cancer Stem Cells as a Source of Biomarkers and Therapeutic Targets. European Urology. (2015) Jan;67(1):7-10. Available from: 10.1016/j.eururo.2014.09.005

Rane JK, Ylipää A, Adamson R, Mann VM, Simms MS, Collins AT, Visakorpi T, Nykter M, Maitland NJConstruction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.  Br J Cancer. (2015) Jul 23. doi: 10.1038/bjc.2015.262.

Zoni E, van der Horst G, van de Merbel AF, Chen L, Rane JK, Pelger RC, Collins AT, Visakorpi T, Snaar-Jagalska BE, Maitland NJ, van der Pluijm G.miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6 Integrin Expression.  Cancer Res. (2015) Jun 1;75(11):2326-36. doi: 10.1158/0008-5472.CAN-14-2155. Epub 2015 Apr 9.

Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T.CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. (2015) Apr 19. 6, 23p 19661-19670 10 p.

Hirst AM, Simms MS, Mann VM, Maitland NJ, O'Connell D, Frame FM. (2015)  Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells. Br J Cancer. (2015) 112, 9, p 1536-1545 10 p. Apr 2. doi: 10.1038/bjc.2015.113.

Wanger TM, Dewitt S, Collins A, Maitland NJ, Poghosyan Z, Knäuper V.  Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cell Signal. (2015) Mar 26. pii: S0898-6568(15)00116-3. doi: 10.1016/j.cellsig.2015.03.017. Epub ahead of print

Santer FR, Erb HH, Oh SJ, Handle F, Feiersinger GE, Luef B, Bu H, Schäfer G, Ploner C, Egger M, Rane JK, Maitland NJ, Klocker H, Eder IE, Culig Z.  Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy. (2015) Oncotarget. 6, 8, p6105-6122 118 p.  

Maitland NJCarcinoma-derived exosomes modify microenvironment.  Oncotarget. (2015) Jan 30;6(3):1344-5 2 p.


Rane JK., Scaravilli M., Ylipaa A., Pellacani D., Mann VM., Simms MS.,  Nykter M., Collins AT., Visakorpi T., Maitland NJ.  (2014) MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets.  European Urology DOI: 10.1016/j.eururo.2014.09.005 (In Press)

Rane JK, Droop AP, Pellacani D, Polson ES, Simms MS, Collins AT, Caves LSD, Maitland NJ (2014) Conserved two step regulatory mechanism of human epithelial differentiation. Stem Cell Reports. 2:1-9

Pellacani D, Kestoras D, Droop AP, Frame FM, Berry PA, Lawrence MG, Stower MJ, Simms MS, Mann VM, Collins AT, Risbridger GP, Maitland NJ (2014) DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation. Cell Death and Differentiation. 1-13

Maitland NJ. (2014)  The Future: what’s in the toolkit for prostate cancer diagnosis and treatment? In: Prostate Cancer: Diagnosis and clinical management (Wiley and Sons Ltd) Eds: Tewari AK, Whelan P, and Graham JD. Chapter 17, 313

Maitland N J, Collins A T. (2014) The hallmarks of prostate cancer stem cells. V K Rajasekhar (Editor) Cancer Stem Cells, Wiley Press (Book Chapter – Accepted for publication)


F M Frame, D Pellacani, A T Collins, M S Simms, V M Mann, GDD Jones, M Meuth, R G Bristow and N J Maitland (2013) HDAC inhibitor confers radiosensitivity to prostate stem-like cells. British Journal of Cancer 109, 3023–3033. doi:10.1038/bjc.2013.691

Kroon P., Berry PA.., Stower MJ., Rodrigues G, Mann VM., Simms M., Deepak Bhasin D., Chettiar S., Li C, Li P-K., Maitland NJ,  *Collins AT. JAK-STAT blockade inhibits tumour initiation and clonogenic recovery of prostate cancer stem-like cells.  Cancer Research 73, 2013, 5288-5298. 

Maitland NJ (2013) A fusion at the root of prostate cancer. Asian J Androl. 2013 Jun 10. doi: 10.1038/aja.2013.75. [Epub ahead of print]

Maitland NJ (2013) Re: Prognostic Value of Blood mRNA Expression Signatures in Castration-resistant Prostate Cancer: A Prospective, Two-stage Study. Eur Urol. 2013 Aug;64(2):341-2. doi: 10.1016/j.eururo.2013.05.014.

Ulukaya E, Frame FM, Cevatemre B, Pellacani D, Walker H, Mann VM, Simms MS, Stower MJ, Yilmaz VT, Maitland NJ (2013) Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. PLoS One. 2013 May 10;8(5):e64278. doi: 10.1371/journal.pone.0064278.

Polson, ES, Lewis JL, Celik H, Mann VM, Stower MJ, Simms MS, Rodrigues G, Collins AT, Maitland NJ.  (2013) Mono-allelic expression of TMPRSS2/ERG in prostate cancer stem cells. Nature Communications, 2013;4:1623. doi: 10.1038/ncomms2627.

Oldridge EE, Walker HF, Stower MJ, Simms MS, Mann VM, Collins AT, Pellacani D, Maitland NJ. (2013) Retinoic acid represses invasion and stem cell phenotype by induction of the metastasis suppressors RARRES1 and LXN.  Oncogenesis 2013 Apr 15;2:e45. doi: 10.1038/oncsis.2013.6.

Lawrence MG, Taylor RA, Toivanen R, Pedersen J, Norden S, Pook  DW,  Frydenberg M, Australian Prostate Cancer BioResource5, Papargiris MM,  Niranjan B, Richards MG, Wang H,  Collins AT, Maitland NJ Risbridger GP. (2013)  A preclinical xenograft model of prostate cancer using human tumours. Nat Protoc. 2013 May;8(5):836-48. doi: 10.1038/nprot.2013.043. Epub 2013 Apr 4.

Pellacani, D., Oldridge, E. E. , Collins, A. T. & Maitland, N. J. (2013) Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells In : Advances Exp Med Biol. 777, p. 167-84.

Yu D, Jin C, Ramachandran M, Xu J, Nilsson B, Korsgren O, Le Blanc K, Uhrbom L, Forsberg-Nilsson K, Westermark B, Adamson R, Maitland N, Fan X, Essand M. (2013) Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures. PLoS One. 2013;8(1):e54952. doi: 10.1371/journal.pone.0054952. Epub 2013 Jan 25.

Maitland N J (2013) Stem cells in the normal and malignant prostate.  D J Tindall (Editor), Prostate Cancer: Biochemistry, Molecular Biology and Genetics, Protein Reviews 16, DOI 10.10007/978-1-4614-6828-8_1 Mayo Clinic (Book Chapter)

Frame F M, Maitland N J. (2013) Cancer stem cells provide new insights into the therapeutic responses of human prostate cancer. S Cramer (Editor), Stem Cells and Prostate Cancer, DOI 10.1007/978-1-4614-6498-3­_4 Springer Science + Business Media (Book Chapter)

Maitland N J, Collins A T. (2013) The hallmarks of prostate cancer stem cells. V K Rajasekhar (Editor) Cancer Stem Cells, Wiley Press (Book Chapter)

Swift S.L, Rivera G.C, Dussupt V, Leadley R.M, Hudson L.C, de Ridder C.M, Kraaji R, Burns J.E,  Maitland N.J,  Georgopolous L.  (2013) Evaluating baculovirus as a vector for human prostate cancer gene therapy. PLoS One. 2013 Jun 6;8(6):e65557. doi: 10.1371/journal.pone.0065557.


Adamson RE, Frazier AA, Evans H, Chambers KF, Schenk E, Essand M, Birnie R, Mitry RR, Dhawan A, Maitland NJ.  In Vitro Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus. Hum Gene Ther. Hum Gene Ther. 2012 Feb;23(2):218-30. doi: 10.1089/hum.2011.021.

Magnusson MK, Kraaij R, Leadley RM, De Ridder CM, van Weerden WM, Van Schie KA, Van der Kroeg M, Hoeben RC, Maitland NJ, Lindholm L. A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer. Hum Gene Ther. Hum Gene Ther. 2012 Jan;23(1):70-82. doi: 10.1089/hum.2011.016.

Frame FM, Maitland NJ. Cancer stem cells, models of study and implications of therapy resistance mechanisms. Adv Exp Med Biol. 2011;720:105-18.

Oldridge EE, Pellacani D, Collins AT, Maitland NJ. (2012) Prostate cancer stem cells: Are they androgen-responsive?  Mol Cell Endocrinol. Sep 5;360(1-2):14-24.

Rane, J. K. , Pellacani, D. & Maitland, N. J. (2012) Advanced prostate cancer-a case for adjuvant differentiation therapy   In : Nature reviews. Urology. 9, 10, p. 595-602.

Rivera-Gonzalez,  GC, Droop, AP, Rippon, HJ, Tiemann,K,  Pellacani, D, Georgopoulos LJ and Maitland, NJ.  (2012)  Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significance. Nucleic Acids Res. 40: 4825-4840.

Taylor RA, Toivanen R, Frydenberg M, Pedersen J, Harewood L, Australian Prostate Cancer Bioresource, Collins AT, Maitland NJ, Risbridger GP. (2012) Human Epithelial Basal Cells Are Cells of Origin of Prostate Cancer, Independent of CD133 Status. Stem Cells. Jun;30(6):1087-96.

Klein S, Frame F M and Maitland N J. (2012) Therapy Resistance in Prostate Cancer: A stem cell perspective. Book Chapter ‘Stem Cells and Regenerative Medicine: Progress and Challenges’ (Springer Science + Business Media LLC)


Frame F.M. and Maitland N.J. (2011)
Cancer stem cells, models of study and implications of therapy resistance mechanisms. Proceedings of the 2010 Montreal Conference on Human Cell Transformation: Role of Stem Cells and the Microenvironment, McGill University, Montreal, Canada. (Book chapter).

Davide Pellacani, Richard J Packer, Fiona M Frame, Emma E Oldridge, Paul A Berry, Michael J Stower, Matthew S Simms, Anne T Collins, Norman J Maitland. Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer. Mol Cancer. Jul 29;10:94. doi: 10.1186/1476-4598-10-94.

Paul A Berry, Richard Birnie, Alastair P Droop, Norman J Maitland, Anne T Collins. (2011) The calcium sensor STIM1 is regulated by androgens in prostate stromal cells. Prostate. Nov;71(15):1646-55. doi: 10.1002/pros.21384.

Maitland, NJ., Frame, FM., Polson ES., Lewis JL. and Collins AT. (2011)
Prostate Cancer Stem Cells: Do They Have a Basal or Luminal Phenotype?
Volume 2, Number 1, Pages 47-61.

Rumsby M, Schmitt J, Sharrard M, Rodrigues G, Stower M, Maitland N. (2011) Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C. British Journal of Cancer, 104: 673-84.

Muthana M, Giannoudis A, Scott SD, Fang HY, Coffelt SB, Morrow FJ, Murdoch C, Burton JL, Cross N, Burke B, Mistry R, Hamdy F,Brown NJ, Georgopoulos L, Hoskin PJ, Essand M, Lewis C, Maitland NJ. (2011) Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors. Cancer Research 71: 1805-15

Maitland N.J., Frazier A., Birnie., Nicholl A. and Collins A. (2011) Primary Culture and Propagation of Human Prostate Epithelial Cells. Epithelial Cell Culture (2nd Edition) Methods in Molecular Biology, Humana Press.

Rivera-Gonzalez GC, Swift SL, Dussupt V, Georgopoulos LJ, Maitland NJ.  Baculoviruses as gene therapy vectors for human prostate cancer. J Invertebr Pathol. 2011 Jul;107 Suppl:S59-70.


de Vrij J, Willemsen RA, Lindholm L, Hoeben RC; GIANT Consortium, Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ,de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F,Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P,Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G. (2010) Adenovirus-derived vectors for prostate cancer gene therapy. Human Gene Therapy Jul;21(7):795-805.

Schenk E, Essand M, Bangma CH; GIANT FP6 Consortium, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Danielsson A, Dautzenberg IJ, Dzojic H, Erbacher P, Fisher K, Frazier A, Georgopoulos LJ, Hoeben R, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Lindholm L, Magnusson M, Maitland N, Neuberg P, Nilsson B, Ogris M, Remy JS, Scaife M, Schooten E, Seymour L, Totterman T, Uil TG, Ulbrich K, Veldhoven-Zweistra JL, de Vrij J, van Weerden W, Wagner E, Willemsen R. (2010) Clinical adenoviral gene therapy for prostate cancer. Human Gene Therapy. Jul;21(7):807-13.

Frame FM, Hager S, Pellacani D, Stower MJ, Walker HF, Burns JE, Collins AT, Maitland NJ. (2010) Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells. Exp Cell Res. 316(19):3161-71. 

Maitland NJ, Collins AT. (2010) Cancer stem cells - A therapeutic target? Curr Opin Mol Ther.Dec;12(6):662-73.

Burns JE, Walker HF, Schmitz C, Maitland NJ (2010) Phenotypic effects of HPV-16 E2 protein expression in human keratinocytes. Virology. Jun 5;401(2):314-21.

Maitland N.J., Chambers K., Georgopolous L., Simpson-Holley M., Leadley R., Evans H., Essand M., Danielsson A., van Weerden W., der Ridder C., Kraaij R., Bangma C. H., and members of the GIANT FP6 Consortium. Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems? Human Gene Therapy, 21:815-827 (July 2010)

Swift, SL, Burns, JE and Maitland NJ. (2010) Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. Cancer Research 1;70(1):347-356.


Lang SH., Anderson E., Fordham R  and Collins AT. (2009) Modelling the prostate stem cell niche: an evaluation of stem cell survival and expansion in vitro. Stem Cells and Development

Georgopoulos LJ, Elgue G, Sanchez J, Dussupt V, Magotti P, Lambris JD, Tötterman TH, Maitland NJ, Nilsson B. (2009) Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol Immunol. Sep;46 (15) 2911-7

Collins AT, Maitland NJ. (2009) Prostate cancer: Regeneration of interest in the prostate. Nat Rev Urol. Apr:6 (4) 184-6

Cohen PA, Marek M, Davies BG, Vlak JM and van Oers MM (2009) Encyclopedia of Autographa californica Nucleopolyhedrovirus Genes. Virologica Sinica Aug, 24 (4):359-414.

Lang SH, Frame FM, Collins AT. (2009) Prostate cancer stem cells. J Pathol. 217(2):299-306. Review.


Maitland NJ, Collins AT. (2008) Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection? J Cell Biochem. 105(4):931-9. Review.

Hager S, Frame FM, Collins AT, Burns JE, Maitland NJ. (2008)An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner. Hum Gene Ther. 19(8):840-50.

Maitland NJ, Collins AT. (2008) Prostate cancer stem cells: a new target for therapy. J Clin Oncol. 26(17):2862-70. Review.

Birnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH, Berry PA, Hyde CF, Lewis JL, Stower MJ, Maitland NJ, Collins AT. (2008) Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biol. 9(5):R83.

Berry PA, Maitland NJ, Collins AT. (2008) Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells. Mol Cell Endocrinol. 288(1-2):30-7. Review.

Hernandez-Ramon EE, Burns JE, Zhang W, Walker HF, Allen S, Antson AA, Maitland NJ.  (2008) Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region. J Virol. 82(10):4853-61.


Sharrard RM, Maitland NJ. (2007)  Regulation of Protein Kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.  Cell Signal. 19:129-38.

Maitland N.J., Bryce S., Collins A.T. (2007) Cancer stem cells: Are they the basis of tumour recurrence after treatment for prostate cancer? International Journal of Biological Markers 22 (1): 48-49

Maitland N.J., Bryce S., Stower M.J., Collins A.T. (2007) Prostate cancer stem cells: a target for new therapies. Ernst Schering Found Symp Proc. 5: 155-79

Keith W.N., Tomson C.M., Howcroft J., Maitland N.J., Shay J.W. (2007) Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells. Drug Discov Today. 12: 611-21


Chapel-Fernandes S, Jordier F, Lauro F, Maitland N, Chiaroni J, de Micco P, Mannoni P, Bagnis C. (2006)   Use of the PSA enhancer core element to modulate the expression of prostate- and non-prostate-specific basal promoters in a lentiviral vector context. Cancer Gene Ther. 13:919-29.

Lang SH, Smith J, Hyde C, Macintosh C, Stower M, Maitland NJ. (2006) Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.  In Vitro Cell Dev Biol Anim. 42:273-80.

Dawson, L.A., Maitland, N.J., Berry, P., Turner, A.J., Usmani, B.A. (2006) Expression and localization of endotheline-converting enzyme-1 in human prostate cancer.  Experimental Biology and Medicine 231:1106-10.

Collins, A.T., Maitland, N.J. (2006) Prostate cancer stem cells.  Eur. J Cancer, Jun;42(9):1213-8.


Riddick, A.C.P., Shukla, C.J., Pennington, C.J., Bass, R., Nuttall, R.K., Hogan, A.K., Sethia, K, Ellis, V., Collins, A.T., Maitland, N. J., Ball, R.Y., and Edwards, D.R. (2005) Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.  BJC 92: 2171-2180.

MacRae, E.J., Giannoudis, A., Ryan, R., Brown, N.J., Hamdy, F.C., Maitland, N.J., Lewis, C.E. (2005) Gene Therapy for Prostate Cancer:  Current Strategies and New Cell-Based Approaches.  The Prostate 1-25.

Collins, A.T., Berry, P.A., Hyde, C., Stower, M.J., Maitland, N.J., (2005) Prospective Identification of Tumorigenic Prostate Cancer Stem Cells. Cancer Research 65: (23) 10946-10951.

Maitland, N.J., Collin, A.T. (2005) Making order out of heterogeneity: A tumour stem cell hypothesis for the origins of prostate cancer. BJU International 96: 1219-1223.

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Maitland, N.J., Macintosh, C.A., Schmitz, C., Lang, S.H., (2004) Immortalisation of Human Prostate Cells with the Human Papillomavirus Type 16 E6 Gene. Cancer Cell Culture, Methods and Protocols, Edited by Simon P Langdon (Chapter 26 275-285).

Lang, S.H., Maitland, N.J., (2004) Co-culture of Prostate Cancer Cells.  Cancer Cell Culture, Methods and Protocols, Edited by Simon P Langdon (Chapter 28 295-302) 

Dawson, L., Maitland, N.J., Turner, A.J., Usmani, B.A., (2004) Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression. British Journal of Cancer 90: 1577-1582

Maitland, N.J., Stanbridge L., and Dussupt, V. (2004) Targeting Gene Therapy For Prostate Cancer. Current pharmaceutical design 10: 531-555

Richardson, G.D., Robson, G.N., Lang, S.H., Neal, D.E., Maitland, N.J., Collins, A.T. (2004) CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science 117: 3539-3545

Lipinski, K.S., Djeha, H.A., Gawn, J., Cliffe, S., Maitland, N.J., Palmer, D.H., Mountain, A., Irvine, A.S., Wrighton, C.J. (2004) Optimization of a synthetic ß-catenin-dependent promoter for tumour-specific cancer gene therapy. Molecular Therapy 10: 1:150-161

Scaltriti, M., Bettuzzi, S., Sharrard, R.M., Caporali, A., Caccoma, A.E., Maitland, N.J, (2004) Clusterin overexpression in both malignant and nonmaligant prostate epithelial cells induces cell cycle arrest and apoptosis. British Journal of Cancer 91: 1842-1850

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Collins, A.T., Maitland, N.J., (2003) Stem Cells and Cancer: The Origin of Prostate Carcinoma (Prostate Cancer Series: Part One). Cancer Topics 11, 12: 1-5

Burns, J.E., Burn, C.L., Hernandez-Ramon, E., Schmitz, C., Lloansi Vila, A., Maitland, N.J., (2003) Forms and Functions of Papillomavirus E2 Proteins. Recent Research in Biochemistry 4(2003): 795-823

Bastide, C., Maroc, N., Bladou, F., Hassoun, J., Maitland, N.J., Mannoni, P., Bagnis, C., (2003) Expression of a model gene in prostate cancer cells lentivirally transduced in vitro and in vivo. Prostate Cancer and Prostatic Diseases 6: 228-234

Moroz, O.V., Antson, A.A., Grist, S.J., Maitland, N.J., Dodson, G.G., Wilson, K.S., Lukanidin, E., Bronstein, I.B., (2003) Structure of the human S100A12-copper complex: implications for host-parasite defence. Acta Crystallographica Section D59: 859-867

Stanbridge, L., Dussupt, V., Maitland, N.J., (2003) Baculoviruses as Vectors for Gene Therapy against Human Prostate Cancer. Journal of Biomedicine and Biotechnology 2003:2, 79-91

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Lang, S.H., Hyde, C., Reid, I.N., Hitchcock, I.S., Hart, C.A., Gordon Bryden, A.A., Villette, Jean-Marie., Stower, M.J., Maitland, N.J., (2002) Enhanced Expression of Vimentin in Motile Prostate Cell Lines and in Poorly Differentiated and Metastatic Prostate Carcinoma. The Prostate 52: 253-263

Hall, J.A., Maitland, N.J., Stower, M.and Lang, S.H. (2002) Primary Prostate Stromal Cells Modulate the Morphology and Migration of Primary Prostate Epithelial Cells in Type 1 Collagen Gels. Cancer Research 62, 58-62

Davies, H., Bignell, G.R., Cox, C., Stephens, P., Bottomley, W., Davis, N., Hall, S., Hawes, R., Stevens, C., Shipley, J., Maitland, N.J., Paterson, H., Marais, R., Wooster, R., Stratton, M.R., Futreal, P.A., (2002) Mutations of the BRAF gene in human cancer. Nature 417: 949-954

Burke, B., Sumner, S., Maitland, N.J., Lewis, C.E., (2002) Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. Journal of Leukocyte Biology 72: 417-428

Lundqvist, A., Noffz, G., Pavlenko, M., Saeboe-Larssen, S., Fong, T., Maitland, N.J., Pisa, P., (2002) Nonviral and Viral Gene Transfer into Different Subsets of Human Dendritic Cells Yield Comparable Efficiency of Transfection. Journal of Immunotherapy 26: (6) 445-454

Lundqvist, A., Choudhury, A., Nagata, T., Andersson, T., Quinn, G., Fong, T., Maitland, N.J., Pattersson, S., Paulie, S., Pisa, P., (2002) Recombinant Adenovirus Vector Activates and Protects Human Monocyte-Derived Dendritic Cells from Apoptosis. Human Gene Therapy 13, 1541-1549

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Collins, A.T., Habib, F.K., Maitland, N.J. and Neal, D.E. (2001) Identification and isolation of human prostate stem cells based on a2b1 integrin expression. Journal of Cell Science 114, 3865-3872

Svetlana, T., Scott, D.J., Maitland, N.J., Lukanidin, E.M., Bronstein, I.G., (2001) The dimerisation interface of metastasis associated protein S100A4 (Mts1): in vivo and in vitro studies. Journal of Biological Chemistry 276, 24212-24222

Moroz O.V., Antson A.A., Murshudov G.N., Maitland N.J., Dodson G.G., Wilson K.S., Skibshoj I., Lukanidin E.M., Bronstein I.B. (2001) The three-dimensional structure of human S100A12. Acta Crystallographica Section D: Biological Crystallography 57.1, 20-29

Lang, S.H., Stark, M., Collins, A., Paul, A.B., Stower, M.J.and Maitland, M.J. (2001) Experimental Prostate Epithelial Morphogenesis in Response to Stroma and Three-Dimensional Matrigel Culture. Cell Growth & Differentiation 12, 631-640

Lang, S.H.; Sharrard, R.M.; Stark, M.; Villette, J.M.; Maitland, N.J.; (2001) Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures. British Journal of Cancer 85.4: 590 - 599

Bretland, A.J.; Lawry, J.; Sharrard, R.M. (2001) A study of death by anoikis in cultured epithelial cells. Cell Proliferation 34: 199 - 210

Maitland, N.J. (2001) How can prostate-specific gene expression patterns be exploited in the development of tumour gene therapy? British Journal of Cancer 85 (Suppt. S1) Invited Paper S20, page 7

Sharrard, R.M. and Maitland, N.J. (2001) Factors regulating the phosphorylation of protein kinase B/Akt in human prostatic cell lines. British Journal of Cancer 85 (Suppt. S1) Oral Presentation 6.6, page 23

Lang, S.H.; Stark, M.; Hall, J.; Hyde, K.; Stower, M. and Maitland, N.J. (2001) In vitro modelling of the prostate: 3D culture of prostatic cells in Matrigel. British Journal of Cancer 85 (Suppt. S1) Poster 206, page 85

Hall, J.; Stower, M. and Maitland, N.J. (2001) In vitro modelling of the prostate: 3D culture of primary prostate cells in collagen gels. British Journal of Cancer 85 (Suppt. S1) Poster 207, page 86

Usmani, B., Maitland, N.J., Nanus, D.M., Turner, A.J. (2001) Differential expression of ECE and NEP Metalloproteinase in Prostate Cancer. British Journal of Cancer 85 (Suppt. S1) Poster 212, page 87

Scott, L. J.; Clarke, N. W.; George, N. J.; Shanks, J. H.; Testa, N. G.; Lang, S. H. (2001) Interactions of human prostatic epithelial cells with bone marrow endothelium: binding and invasion. British Journal of Cancer 84.10. 1417-1423

Maitland NJ, Macintosh CA, Hall J, Sharrard M, Quinn G and Lang S (2001) In vitro models to study cellular differentiation and function in human prostate cancers. Radiation Research 155 (1): 133-142

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Sharrard, R.M. and Maitland, N.J. (2000) Alternative splicing of the human PTEN/MMAC1/TEP1 gene. Biochimica et Biophysica Acta - Gene Structure and Expression 1494, 282-285

Sharrard, R.M. and Maitland, N.J. (2000) Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells. British Journal of Cancer 83.8 1102-1109

Maitland, N.J. (2000) Targeting therapeutic gene expression to human prostate cancers. Current Opinion in Molecular Therapeutics 2.4, 389-399

Stevenson, M.; Hudson, L.C.; Burns, J.E.; Stewart, R.L.; Wells, M. and Maitland, N.J. (2000) Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraepithelial neoplasia. Journal of General Virology 81 Pt 7, 1825-1832

Waller, A.S., Sharrard, R.M., Berthon, P. and Maitland, N.J. (2000) Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, Casodex. Journal of Molecular Endocrinology 24, 339-351

Antson, A.A., Burns, J.E., Moroz, O.V., Scott, D.J., Sanders, C.M., Bronstein, I.B., Dodson, G.G., Wilson, K.S. and Maitland, N.J. (2000) Structure of the intact transactivation domain of the human papillomavirus E2 protein. Nature 403, 805-809

Lang, S.H., Stower, M. and Maitland, N.J. (2000) In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates. British Journal of Cancer 82.4, 990-997

Murant, S.J., Rolley, N., Phillips, S.M., Stower, M. and Maitland, N.J. (2000) Allelic imbalance within the E-cadherin gene is an infrequent event in prostate carcinogenesis. Genes Chromosomes and Cancer 27104-109

The Cancer Research Unit draws its research funding from a number of sources both local, National and International.

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