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Proteomics Service

Our highly experienced proteomics team offer a wide range of LC-MS/MS-based proteomic services from focused single protein quality control, to targeted PTM analyses, to whole proteome quantification studies.

Quantification workflows include: label free (intensity-based and spectral counting), isobaric labelling (TMT and iTRAQ), in-vivo labelling (SILAC and 15N) and absolute quantification (AQUA and QconCAT).

Our PTM services can provide site mapping for many modifications including: phosphorylation, methylation, acetylation, ubiquitination and both N- and O-glycosylation.

Quality control options for single protein analyses can yield terminal sequencing by MALDI-ISD, maximum sequence coverage with multiple proteases and disulfide bond count.

Our state of the art mass spectrometry instrumentation, including an Orbitrap Fusion Tribrid and solariX-XR FT-MS, allow us to provide the latest analysis workflows with the highest quality.  Notably the Orbitrap Fusion affords multi-notch MS3 generating the highest accuracy TMT-based quantification.

We have access to a suite of software options for optimal interrogation of data including Progenesis QI, Scaffold Q+S and Mascot Distiller.

Please contact us regarding the options listed above or any other proteomic analyses you are interested in. We are more than happy to discuss the best options to answer your biological questions and to advise on any aspect proteomic experimental design.

Proteomics Right Col Img

Bruker ultraflex III