Mass spectrometry is a powerful method for profiling, identifying and quantifying small molecules, for which we use both GC-MS and LC-MS techniques. The unparalleled resolution and mass accuracy of our solariX FT-MS means that molecules can often be confidently identified from their accurate mass alone (see case study). Absolute quantification of small molecules, for examples drugs and their metabolites, can be performed by MRM using our Thermo Endura triple-quadrupole instrument. We can also provide HRAM services for untargeted metabolomics using our Bruker maXis HD or Thermo Orbitrap Fusion instruments.
Each small-molecule problem is unique, so please inquire about your specific requirements.