Module 101: Molecular Biology and Biochemistry of the Cell (Year 1)
My contribution focuses on bioenergetics. The concepts of Gibbs free energy and of redox potentials are introduced. Electron transport and ATP synthesis in mitochondria are discussed in the context of chemiosmotic coupling. Light as an energy source for photosynthesis is discussed in quantitative terms and the nature of higher plant light driven electron transport and NADPH synthesis is described. Fixation of CO2, leading to the production of sucrose and starch, is considered as well as the metabolic pathway involved in photorespiration.
Module 502: Membrane Biogenesis and Transport (Year 2)
My lectures in this module are reviews of the structural and functional diversity of membrane transport systems. They focus on the mechanistic insights that have emerged from crystallographic studies on membrane proteins.
Module 711: Molecular Machines (Year 3)
I give just two lectures here: one on rotary catalysis by F-type ATPases and one on the bacterial flagellar rotor.
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