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|1999 -||Professor of Molecular Carcinogenesis & Director of the Jack Birch Unit of Molecular Carcinogenesis||Department of Biology, University of York|
|1993 - 1999||Head of ICRF Lab 'Biology of Normal and Malignant Epithelial Cells'||Cancer Medicine Research Unit, University of Leeds|
|1990 - 1999||Research Fellow, then Senior then Principal Research Fellow||Cancer Medicine Research Unit, University of Leeds|
|1989||PhD||University of Leeds|
|1983||GI Biol (2:1 Hons)||Institute of Biology|
|1978 - 1990||Research Officer||Imperial Cancer Research Fund|
Research Focus lead for Molecular & Cellular Medicine
Member of the Biology Department Research Committee
Theme Lead for Molecular Cell Medicine for York Biomedical Research Institute (YBRI)
Professor Jenny Southgate is Director of the Jack Birch Unit for Molecular Carcinogenesis (JBU) and holds a Research Chair funded externally by York Against Cancer. The research of the JBU focuses on human epithelial tissues and their cancers. Our aims are to understand the processes that control proliferation, differentiation and cellular organisation in normal and wounded epithelial tissues and how dysregulation of these processes leads to the development and progression of malignant disease. Most of the work in the Unit focuses on urothelium, the specialised epithelium that lines the urinary tract and gives rise to bladder cancer. A range of cell and tissue culture systems have been developed to study urothelial cells from normal and diseased tissues, and methods have been established using retroviruses to enable gene manipulation in order to recapitulate the early stages of neoplastic development. The capacity for in vitro-propagated normal human urothelial cells to undergo differentiation and form a functional urinary barrier has led to an interest in reconstructing urothelial cells into functional tissues for the purpose of tissue engineering and we are also examining the use of natural biomaterials as scaffolds for this purpose.
|Postdoctoral Research Associate||The Urotheliome|
|Postdoctoral Research Fellow||Identification of therapeutic targets to modulate urothelial remodelling for interstitial cystitis.|
|Dr Sreemoti Banerjee||Postdoctoral Research Associate||
An alternative, non-hierarchical epigenetically regulated model of the urothelium
|Dr Jenny Hinley||URoBank Manager & Senior Research Technician|
|Research Technician managing Microbiology & Molecular Biology Facilities|
|Research Technician managing Tissue Culture Facilities||
|Dr Claire Varley||Research Technician||Identification of therapeutic targets to modulate urothelial remodelling for interstitial cystitis|
|Olivia Foody||Junior Research Technician||Identification of therapeutic targets to modulate urothelial remodelling for interstitial cystitis|
|Dr Debora Morgante||Clinical Research Fellow/PhD Student||Bladder derived natural acellular matrices for homologous urinary tract surgical applications|
|Tom Crighton||PhD Student||Differentiation-dependent growth regulation in bladder cancer|
|Zhen Liu||PhD Student||Compartmentalisation of PPARγ during differentiation and neoplastic transformation|
Available PhD research projects
Self-funded PhD Studentship (example below)
Homeostatic mechanisms in human urothelium: balancing of tissue regeneration and differentiation with implications for regenerative medicine and cancer
The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier. Although normally a mitotically-quiescent tissue, urothelium shows a rapid and highly regenerative response to damage. Whether there is a specific progenitor or stem cell population remains controversial, as no such cell has been unequivocally identified. An alternative hypothesis is that all cells remain capable of switching into a regenerative phenotype, irrespective of differentiation state. The project will examine this hypothesis in a well-established cell culture system, using a combination of cell and molecular biology approaches to examine the role of cell:cell interactions, downstream signal transduction and epigenetic regulation.
Supervisor: Professor Jennifer Southgate (Biology, JBU)
Please contact Professor Jennifer Southgate: firstname.lastname@example.org if you would like to discuss this or other self-funded projects that may be available.
As the holder of a Research Chair, I am passionate about science and “passing on the torch” to the next generations of young scientists. My teaching goal is to instil how underpinning scientific principles and learning can be combined with robust research practices to advance scientific knowledge and its translation into clinical and medical advances.
I currently lecture on the 3rd year module Cell and Tissue Engineering. As a relatively new and multidisciplinary research field, this provides an exciting forum to explore how research can be driven by the practical goal of addressing clinical need, alongside some of the particular challenges that face translation into the clinic. My approach in these lectures is to provide a framework of clinical need, illustrate how basic scientific knowledge can be applied in a multidisciplinary research setting and use examples, including my own research, to demonstrate possible approaches. We also take a look at some examples from the literature to illustrate the importance of incorporating sound scientific and ethical principles in order to avoid the risk of doing harm.
I am a visiting lecturer on the Master Program in Bioengineering at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland (since 2010).
I offer a stage two tutorial in the area of “epithelial tissue homeostasis and cancer”. The content is not prescribed as I see this as the starting point for encouraging self-directed learning and thinking by students through discussion. I aim to support the development of key academic research skills through practice with presentations and reports. Frequently we review research papers selected and brought to the tutorial by the students, with the aim of developing a critical eye to sourcing and evaluating the literature.
I am particularly enthusiastic that through the final year projects, we are able to offer the opportunity for undergraduate students to join us in the Jack Birch Research Unit to sample the environment of the well-run research unit for future career decisions. Projects are invariably aligned to our current research, with laboratory mentoring by members of the research team. We pride ourselves in providing high quality training in experimental design and research techniques which may include cell and tissue culture, histology, microscopy, RNA isolation and analysis using PCR amplification techniques, and protein analysis by western blotting and immunochemistry.