Professor Jenny Southgate
Director, Jack Birch Unit

Profile

Career

1999 - Professor of Molecular Carcinogenesis & Director of the Jack Birch Unit of Molecular Carcinogenesis Department of Biology, University of York
1993 - 1999 Head of ICRF Group 'Biology of Normal and Malignant Epithelial Cells' Cancer Medicine Research Unit, University of Leeds
1990 - 1999 Research Fellow, then Senior then Principal Research Fellow Cancer Medicine Research Unit, University of Leeds 
1989 PhD University of Leeds
1983 GI Biol (2:1 Hons) Biochemistry Institute of Biology
1978 - 1990 Research Officer Imperial Cancer Research Fund               

Departmental roles

Lead on Molecular & Cellular Medicine Research Peer Review College

Member of the Biology Enterprise Group  

Member of the Biology HYMS Committee

 

University roles

Univ Academic Promotions - Sciences Advisory Board 2013-2014

Chairperson York University Ethics Committee 2001-2012

Research

Overview

Professor Jenny Southgate is Director of the Jack Birch Unit for Molecular Carcinogenesis (JBU) and holds a Research Chair funded externally by York Against Cancer.  The research of the JBU focuses on human epithelial tissues and their cancers.  Our aims are to understand the processes that control proliferation, differentiation and cellular organisation in normal and wounded epithelial tissues and how dysregulation of these processes leads to the development and progression of malignant disease.   Most of the work in the Unit focuses on urothelium, the specialised epithelium that lines the urinary tract and gives rise to bladder cancer.  A range of cell and tissue culture systems have been developed to study urothelial cells from normal and diseased tissues, and methods have been established using retroviruses to enable gene manipulation in order to recapitulate the early stages of neoplastic development. The capacity for in vitro-propagated normal human urothelial cells to undergo differentiation and form a functional urinary barrier has led to an interest in reconstructing urothelial cells into functional tissues for the purpose of tissue engineering and we are examining a range of natural and synthetic biomaterials as scaffolds for this purpose.

Projects

  1. Jack Birch Unit of Molecular Carcinogenesis 5 year support Programme (Funding body:  York Against Cancer).
  2. The Urotheliome (Funding body:  The Astellas European Foundation 2010 prize in urology).
  3. Transcriptional regulation of urothelial cytodifferentiation (Funding body:  BBSRC TGAC Capacity and Capability Challenge Programme).
  4. Urinary tract application for a bladder-derived natural acellular matrix (Funding body:  Regener8 and the Medical Technologies IKC proof of concept award).
  5. Molecular and epigenetic mechanisms of heavy metal toxicity in urothelial carcinogenesis. PhD studentship funded by Yorkshire Cancer Research.
  6. Extrinsic manipulation of urothelial tissue homeostasis via modification of the glycome.  BBSRC iCase PhD Studentship with IntelliHep.
  7. Differentiation-dependent growth regulation in bladder cancer.  PhD studentship funded by York Against Cancer
  8. The effect of GAGs on the barrier function of the bladder.  Self-funded Clinical Research Fellow
  9. Kystis  www.kystis.com

Research group(s)

StatusNameProject

Personal Assistant/Administrator

Marie Fleming Administration
Postdoctoral Research Associate Dr Simon Baker The Urotheliome

Senior Research Technician

Dr Jenny Hinley Laboratory manager and organiser of histology facilities
Research Technician Ros Duke

Autologous cell engineered bladder augmentation and managing the cell culture facilities

Research Technician Dr Jo Pearson Manager of microbiology and molecular biology facilities

Research Student

Tom Crighton Differentiation-dependent growth regulation in bladder cancer

Research Student

Kemi Ayeyemi

Extrinsic manipulation of urothelial tissue homeostasis via modification of the glycome

Research Student Rhiannon McNeill
(writing up)
Molecular and epigenetic mechanisms of heavy metal toxicity in urothelial carcinogenesis
Clinical Research Fellow Becky Phillips 
(writing up)
The effect of GAGs on the barrier function of the bladder
Clinical Research Fellow Debora Morgante Decellularised biomaterials for homologous use in urinary bladder auto-augmentation

Available PhD research projects

 

Self-funded PhD Studentship (example below)

Project Title

Homeostatic mechanisms in human urothelium: balancing of tissue regeneration and differentiation with implications for regenerative medicine and cancer

The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier.  Although normally a mitotically-quiescent tissue, urothelium shows a rapid and highly regenerative response to damage.  Whether there is a specific progenitor or stem cell population remains controversial, as no such cell has been unequivocally identified. An alternative hypothesis is that all cells remain capable of switching into a regenerative phenotype, irrespective of differentiation state.  The project will examine this hypothesis in a well-established cell culture system, using a combination of cell and molecular biology approaches to examine the role of cell:cell interactions, downstream signal transduction and epigenetic regulation.  

Supervisor: Professor Jennifer Southgate (Biology JBU)

Please contact Professor Jennifer Southgate:  Jennifer.southgate@york.ac.uk  if you would like to discuss this or other self-funded projects that may be available.

 

 

 

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Contact details

Prof. Jenny Southgate
Director, Jack Birch Unit
Department of Biology (Area 13)
University of York
York
YO10 5DD

Tel: 01904 328705

http://www-users.york.ac.uk/~biol32/