Professor Paul Genever

Profile

Career

2016 -  Professor Department of Biology, University of York
2013 - 2016 Reader Department of Biology, University of York
2008 - 2013 Senior lecturer Department of Biology, University of York
2003 - 2008 Lecturer Department of Biology, University of York
1993 - 2003 ARC Non-Clinical Career Development Fellowship Department of Biology, University of York
1996 - 1999 Post-Doctoral RA Department of Biology, University of York
1993 - 1996 Post-Doctoral RA Department of Biology, Brunel University, West London
1993 PhD Department of Biochemistry and Molecular Biology, University of Leeds
1989 - 1990 Research Officer Department of Chemical Carcinogenesis, Institute of Cancer Research, London
1989 BSc Biochemistry/ Physiology University of Leeds

Research

Overview

Our work is focused on identifying cellular and molecular pathways that regulate differentiated tissue function, primarily in skeletal systems (bone, cartilage, marrow). This requires an understanding of the fundamental signalling mechanisms that determine adult stem cell fate, tissue remodelling, repair and regeneration and how to apply this knowledge to tissue engineering approaches and the treatment of human disease conditions (orthobiologics).

Discoveries

We discovered that the Wnt signalling cascade plays a fundamental role in bone remodelling, influencing both bone resorption and formation. We have identified and characterised several new tissue sources of adult stem cells and are applying these to tissue engineering approaches. For more details, please see the Genever Lab website.

Available PhD research projects

Analysis of mesenchymal stromal/stem cell sub-populations

Human mesenchymal stromal/stem cells (MSCs) are found in adult tissues such as bone marrow and are able to differentiate into osteogenic, chondrogenic and adipogenic tissues. There is intense interest in determining how MSCs may be used in future cell-based therapies, including gene therapy, immunotherapy and tissue engineering, and as in vitro models for fundamental research and drug discovery. However, little is known about MSC identity and research is often performed on heterogeneous mixtures of different MSC sub-populations. Using a process of telomerase-based immortalisation and cell cloning, we have generated several different MSC lines that represent different “types” of MSCs. For example, some MSC lines demonstrate tri-lineage, whereas other are bi-potent, uni-potent or nulli-potent. This project will examine the differentiation characteristics of these MSC lines to determine how they reflect MSC sub-populations in vivo.

Dr Paul Genever

Contact details

Prof. Paul Genever
Professor
Department of Biology
University of York
York
YO10 5DD

Tel: 01904 328649

http://www.geneverlab.info