Understanding long non-coding RNA function.

Supervisor:  Dr Dimitris Lagos

Co-Supervisors:  Dr Dawn Coverley

Project description:

Our cells use nearly 80% of our DNA, but less than 2% is used for making proteins. The remaining 78% generates non-­‐coding RNAs, which play crucial roles in health and disease. As the vast majority of current drugs act on proteins, non-­‐coding RNAs represent an untapped source of biological mechanistic knowledge and future drug targets. This project will focus on a long non-­‐coding RNA (lncRNA) called Malat1 that was discovered due to its association with cancer metastasis. The successful applicant will investigate the function and regulation of Malat1 in normal, non-­‐cancerous cells, in order to establish its physiological function (why our cells need it). The work will provide important clues about the function of lncRNAs. Understanding lncRNA function is one of the most exciting current challenges in molecular cell biology. The student will employ a broad range of biochemical and molecular cell biology experimental approaches and work as part of an enthusiastic research team.

We strongly encourage you to email the project supervisor prior to submitting an application to discuss your suitability for this project.  Please email: 

Funding:  This is a BBSRC White Rose Doctoral Training Partnership PhD studentship fully funded for 4 years and covers: (i) a tax-free stipend at the standard Research Council rate (£14,533 for 2017-2018, to be confirmed for 2018-2019), (ii) research costs, and (iii) tuition fees at the UK/EU rate.

Please read the 'How to apply' tab before submitting your application.

Applications are now closed

Interviews: Monday 5 and Tuesday 6 February 2018