Disrupted cortical dynamics in autism spectrum disorders

Supervisor:  Dr Darren L Goffin

Co-Supervisor:  Professor Miles Whittington (Hull York Medical School)

Project description:  

There are over 7 billion people on this planet. Yet we are all unique. There is no one else like you. Our uniqueness stems from how our genes and experiences effect activity in the brain. Within your brain there are around 100 billion neurons that are engaged in complex electrical and chemical exchanges with one another. As the activity of these neurons change, so do you. We are interested in understanding how specific neurons and neuronal circuits regulate proper brain function and behaviour. Furthermore, the lab aims to investigate how disease leads to alterations in neuronal activity that leads to alterations in a person’s behaviour and actions.

During this PhD, your research will focus on Rett syndrome, a neurodevelopmental caused by mutations in Methyl-CpG-binding Protein 2 (MECP2). This disease is characterized by loss of hand skills, loss of spoken language, anxiety, and seizures. Your research will combine genetic, imaging, and advanced electrophysiology to reveal how the activity of single neurons and small populations of neurons are affected in Rett syndrome.

We strongly encourage you to email the project supervisor prior to submitting an application to discuss your suitability for this project.  Please email: darren.goffin@york.ac.uk

Funding:  This studentship is fully funded for 3 years by the Department of Biology and covers: (i) a tax-free stipend at the standard Research Council rate (£14,533 for 2017-2018, to be confirmed for 2018-2018), (ii) research costs, and (iii) tuition fees at the UK/EU rate.

Start date: October 2018

Please read the 'How to apply' tab before submitting your application.

Applications are now closed

Interviews will be held on Monday 5 or Tuesday 6 February 2018 - TBC