Complexity of the mononuclear phagocytic system of the skin : from phenotype to functions

Friday 23 June 2017, 1.00PM

Speaker: Dr. Sandrine Henri, CIML Marseille France

The skin is a major barrier protecting the body from microbial invasion. The maintenance of homeostasis in the skin is dependent on homeostatic immunity of skin-resident immune cells that interact with skin commensals (bacteria, viruses, parasites and fungi). The skin is also a hotspot of chronic inflammatory disorders such as psoriasis or atopic dermatitis.

Dendritic cells (DCs) and macrophages are key players in the skin. DCs sample the micro-environment and then initiate and guide T cell responses towards immunity or tolerance whereas macrophages contribute to tissue homeostasis. Lately, we contributed to the identification of several monocyte, macrophage and DC subsets in the skin. We unveiled specific function for a given DC subset. In particular, we identified the dermal XCR1+ cDC1 subset which has potent cross-presentation function. Based on this knowledge, we demonstrated that targeting dermal XCR1+ DCs with tumor vaccines induces potent antitumor responses. We also developed innovative mouse-models to study the functions of DC subset and macrophages in vivo.

The host for this seminar is Audrey Romano

More on Centre d’Immunologie de Marseille-Luminy

Location: K/018

Email: cii@york.ac.uk

Telephone: 01904 328845