Producing platelets in vitro: challenges and rewards from using pluripotent stem cells

Friday 17 November 2017, 1.00PM

Speaker(s): Dr Cedric Ghevaert, Senior Lecturer in Transfusion Medicine, University of Cambridge/ Consultant Haematologist, NHS Blood and Transplant

Pluripotent stem cells offer a real opportunity to produce somatic tissues for clinical use. Our interest is in producing platelets for transfusion for patients at risk of bleeding. To this end we use a forward programming technology based on the over expression of key transcription factors to maximise cell output and final product purity. We also use genome editing in order to produce platelets with added value: reduce immunogenicity, enhanced clotting and tissue repair. We also use a bioengineering approach  to enhance platelet release by reproducing the bone marrow environment in 3D scaffolds.

The host for this seminar is Professor Ian Hitchcock 

Location: K018