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Immune-mediated control of Toxoplasma and Salmonella in human cells

Friday 20 November 2020, 1.00PM

Speaker(s): Dr Eva Frickel, University of Birmingham

Infection with intracellular pathogens such as the parasite Toxoplasma gondii and the bacterium Salmonella typhimurium generates the cytokine interferon gamma (IFNg). IFNg stimulates cells to upregulate host defence proteins, amongst them the interferon-inducible guanylate binding proteins (GBPs). GBPs promote cell-intrinsic defense by targeting pathogens and pathogen-containing vacuoles for membrane-disruption that releases microbial molecules to induce host cell death. GBP1 mediates pyroptosis or atypical apoptosis of Salmonella- or Toxoplasma-infected human macrophages, respectively. We have developed an artificial intelligence-driven image analysis pipeline (HRMAn, Host Response to Microbe Infection) enabling us to conduct high throughput single-cell analysis of these host defence mechanisms. Combined with mechanistic cellular studies and unbiased mass spectrometry approaches, we are addressing the host cell intrinsic defence pathways driven by GBPs in response to these two evolutionarily divergent pathogens.

The seminar will be hosted using Zoom. A Google calendar invite featuring the Zoom link will be sent to Biology staff and students before the seminar date. For all enquiries please contact Biology DMT Hub.

Location: Zoom (online)